| Aaron E. Henry Community Health Services Center Inc. | Health Care and Social Assistance | $1,472,410 | $1,485,359 | 137 | N/A |  Research |
| Aaron E. Henry Community Health Services Center, Inc. | Health Care and Social Assistance | $1,472,400 | $1,482,646 | 137 | N/A | Research |
| Region I Mental Health Commission | Health Care and Social Assistance | $1,094,953 | $1,105,628 | 170 | N/A | Research |
| Region I Mental Health Commission | Health Care and Social Assistance | $966,345 | $971,875 | 159 | N/A | Research |
| The Kbh Corporation | Manufacturing | $938,200 | $944,012 | 117 | $30.6M | Research |
| Saf T Cart INC | Manufacturing | $886,500 | $891,597 | 98 | $24.0M | Research |
| Saf T Cart INC | Manufacturing | $814,652 | $820,762 | 98 | $24.0M | Research |
| Standard Industrial Park Dr | Manufacturing | $571,800 | $574,770 | 57 | $13.9M | Research |
| Image Industries INC | Manufacturing | $458,481 | $461,220 | 55 | $13.4M | Research |
| Image Industries, INC | Manufacturing | $455,000 | $457,558 | 59 | $14.4M | Research |
| Farrell Gin Company Inc. | Agriculture, Forestry, Fishing and Hunting | $372,400 | $235,604 | 59 | <$5M | Research |
| Circle S Irrigation INC | Agriculture, Forestry, Fishing and Hunting | $369,000 | $372,791 | 34 | <$5M | Research |
| Southern Duplicating of Clarksdale | Real Estate and Rental and Leasing | $320,000 | $321,824 | 30 | $13.6M | Research |
| St. Giab INC | Retail Trade | $300,600 | $304,298 | 203 | $35.4M | Research |
| St Giab INC | Retail Trade | $300,600 | $301,868 | 200 | $34.9M | Research |
| Lula Rich Educational Foundation INC | Educational Services | $245,100 | $246,475 | 35 | N/A | Research |
| Delta Bus Lines, Inc. | Transportation and Warehousing | $240,800 | $243,175 | 21 | $8.1M | Research |
| Tri-State Termite & Pest Control Co | Administrative and Support and Waste Management | $222,300 | $223,875 | 26 | $5.6M | Research |
| Nature's Catch LLC | Agriculture, Forestry, Fishing and Hunting | $212,921 | $213,551 | 19 | <$5M | Research |
| Sb Construction LLC | Construction | $206,250 | $207,436 | 15 | $5.6M | Research |
| Merkel and Cocke PA | Professional, Scientific, and Technical Services | $202,750 | $203,905 | 25 | $6.1M | Research |
| Lula Rich Educational Foundation INC | Educational Services | $198,240 | $199,688 | 26 | N/A | Research |
| Clarksdale Country Club | Arts, Entertainment, and Recreation | $191,600 | $192,803 | 30 | N/A | Research |
| Clarksdale Collegiate | Educational Services | $186,500 | $188,687 | 40 | N/A | Research |
| Family First Clinic of Clarksdale, Pl | Health Care and Social Assistance | $180,300 | $181,797 | 16 | <$5M | Research |