| Tri-State Utility Contractors, Inc. | Construction | $310,600 | $312,343 | 28 | $8.7M |  Research |
| Coldwater Vision Center LLC | Health Care and Social Assistance | $195,732 | $197,809 | 24 | $5.6M | Research |
| Coldwater Vision Center, LLC | Health Care and Social Assistance | $195,725 | $198,433 | 24 | $5.6M | Research |
| Pravinchandra P Patel MD PC | Health Care and Social Assistance | $171,700 | $173,408 | 21 | $6.6M | Research |
| North Mississippi Grain Co. Inc. | Wholesale Trade | $158,703 | $160,768 | 13 | <$5M | Research |
| North Mississippi Grain Co, Inc. | Wholesale Trade | $158,700 | $159,609 | 13 | <$5M | Research |
| Reigning Entertainment | Information | $135,000 | $136,761 | 18 | <$5M | Research |
| Eddie Irby | Transportation and Warehousing | $105,653 | $106,281 | 13 | <$5M | Research |
| Robert L. Kubler | Wholesale Trade | $100,440 | $101,227 | 28 | $7.2M | Research |
| Coldwater Pharmacy | Retail Trade | $94,850 | $95,669 | 6 | <$5M | Research |
| Metal Tech Fabricators INC | Manufacturing | $92,757 | $93,354 | 9 | <$5M | Research |
| Metal-Tech Fabricators, Inc. | Manufacturing | $88,320 | $89,040 | 11 | <$5M | Research |
| Northwest Mississippi Veterinary Services | Professional, Scientific, and Technical Services | $79,000 | $79,673 | 9 | <$5M | Research |
| North Mississippi Adult Day Care Services LLC | Health Care and Social Assistance | $76,935 | $48,271 | 19 | <$5M | Research |
| Penny a Kelly | Administrative and Support and Waste Management | $62,535 | $62,999 | 11 | <$5M | Research |
| Greenleaf Farms | Agriculture, Forestry, Fishing and Hunting | $62,402 | $62,730 | 10 | <$5M | Research |
| Greenleaf Farms | Agriculture, Forestry, Fishing and Hunting | $62,400 | $62,713 | 10 | <$5M | Research |
| North Mississippi Steel Haulers LLC | Wholesale Trade | $62,321 | $63,146 | 7 | <$5M | Research |
| Wakefield Farms | Agriculture, Forestry, Fishing and Hunting | $59,040 | $59,451 | 2 | <$5M | Research |
| D and D Security Systems LLC | Administrative and Support and Waste Management | $53,300 | $53,840 | 5 | <$5M | Research |
| Will Hancock Termite & Pest Control LLC | Administrative and Support and Waste Management | $51,840 | $52,246 | 7 | <$5M | Research |
| D and D Security Systems LLC | Administrative and Support and Waste Management | $51,709 | $52,138 | 5 | <$5M | Research |
| Wakefield Farms | Agriculture, Forestry, Fishing and Hunting | $51,155 | $51,644 | 2 | <$5M | Research |
| Cardinal Sales, Inc. | Manufacturing | $51,138 | $51,645 | 4 | <$5M | Research |
| Cardinal Sales Inc. | Manufacturing | $51,137 | $51,959 | 4 | <$5M | Research |