| Dr Arenia C. Mallory Community Health Center | Health Care and Social Assistance | $808,982 | $814,533 | 88 | N/A |  Research |
| Lexington Concrete and Block Company | Manufacturing | $563,400 | $567,845 | 44 | $43.6M | Research |
| Hammett Gravel Company INC | Mining, Quarrying, and Oil and Gas Extraction | $379,000 | $381,116 | 29 | <$5M | Research |
| Don Barrett PA | Professional, Scientific, and Technical Services | $242,700 | $244,581 | 19 | <$5M | Research |
| Central Holmes Christian School | Educational Services | $202,735 | $190,565 | 44 | N/A | Research |
| Central Holmes Christian School | Educational Services | $188,100 | $189,317 | 36 | N/A | Research |
| Garrette Dumptruck Service | Transportation and Warehousing | $164,348 | $165,766 | 11 | <$5M | Research |
| Chenoa Coffee Company | Manufacturing | $106,600 | $107,420 | 10 | <$5M | Research |
| The Powell Company | Unknown | $94,600 | $95,441 | 16 | N/A | Research |
| Deborah Seals | Retail Trade | $83,345 | $83,660 | 5 | <$5M | Research |
| Sdi of Lexington, LLC | Accommodation and Food Services | $81,960 | $82,648 | 12 | <$5M | Research |
| Chenoa Coffee Company | Manufacturing | $81,200 | $81,789 | 5 | <$5M | Research |
| Precision Care Services of Mississippi LLC | Health Care and Social Assistance | $54,500 | $54,805 | 6 | <$5M | Research |
| Precision Care Services of Mississippi LLC | Health Care and Social Assistance | $54,500 | $54,915 | 6 | <$5M | Research |
| Kirklin Brothers Trucking | Transportation and Warehousing | $50,000 | $50,301 | 8 | <$5M | Research |
| T & K Farms | Agriculture, Forestry, Fishing and Hunting | $49,043 | $49,410 | 7 | <$5M | Research |
| T & K Farms | Agriculture, Forestry, Fishing and Hunting | $48,500 | $48,934 | 7 | <$5M | Research |
| Cotton Creek Farms | Agriculture, Forestry, Fishing and Hunting | $46,931 | $47,104 | 3 | <$5M | Research |
| Cotton Creek Farms | Agriculture, Forestry, Fishing and Hunting | $46,931 | $47,305 | 1 | <$5M | Research |
| Trytrucking | Transportation and Warehousing | $45,000 | $45,445 | 1 | <$5M | Research |
| Heather Killebrew Tutor Dmd PA | Health Care and Social Assistance | $44,653 | $45,043 | 10 | <$5M | Research |
| Landfair Auto Transport LLC | Transportation and Warehousing | $41,300 | $37,733 | 1 | <$5M | Research |
| Lexington Home Center, LLC | Retail Trade | $39,800 | $40,063 | 8 | <$5M | Research |
| Sothern Barrel LLC | Accommodation and Food Services | $38,309 | $38,623 | 2 | <$5M | Research |
| Big Johnnys Lawn Services LLC | Administrative and Support and Waste Management | $38,084 | $38,269 | 5 | <$5M | Research |