| George County Hospital | Health Care and Social Assistance | $4,000,892 | $4,047,259 | 365 | $72.4M |  Research |
| Shoemaker Transport Services INC | Transportation and Warehousing | $797,935 | $802,417 | 40 | $6.0M | Research |
| Walt Massey Automotive INC | Retail Trade | $795,612 | $800,277 | 49 | $12.3M | Research |
| T C Construction INC | Construction | $784,156 | $795,263 | 36 | $41.0M | Research |
| Tc Construction, INC | Construction | $779,000 | $792,531 | 36 | $11.5M | Research |
| Shoemaker Transport Services Inc. | Transportation and Warehousing | $732,760 | $737,317 | 38 | $5.7M | Research |
| George County Hospital | Health Care and Social Assistance | $510,600 | $516,126 | 58 | $11.5M | Research |
| Industrial/commercial Fire Protection, Inc. | Construction | $391,500 | $395,340 | 31 | $35.3M | Research |
| George Regional Health & Rehab | Health Care and Social Assistance | $366,947 | $370,918 | 49 | $9.7M | Research |
| Complete Welding Solutions INC | Manufacturing | $362,553 | $367,559 | 12 | <$5M | Research |
| Complete Welding Solutions, Inc. | Manufacturing | $362,500 | $369,998 | 10 | <$5M | Research |
| Magnolia Trailers INC | Manufacturing | $351,300 | $354,014 | 28 | $7.3M | Research |
| Magnolia Trailers INC | Manufacturing | $341,053 | $343,706 | 27 | $7.1M | Research |
| Davis Industrial Services, INC | Other Services (except Public Administration) | $315,700 | $318,533 | 18 | <$5M | Research |
| Rocky L Mcgarity INC | Retail Trade | $310,300 | $314,610 | 55 | $9.6M | Research |
| Cvm, LLC | Retail Trade | $304,200 | $306,800 | 68 | $22.8M | Research |
| Courtney Farms, LLC | Agriculture, Forestry, Fishing and Hunting | $279,400 | $281,589 | 43 | <$5M | Research |
| Courtney Farms LLC | Agriculture, Forestry, Fishing and Hunting | $271,912 | $275,190 | 83 | $8.5M | Research |
| Fryfogle Manufacturing, Inc. | Manufacturing | $265,954 | $268,322 | 26 | $6.8M | Research |
| Batson & Brown Inc. | Professional, Scientific, and Technical Services | $234,443 | $236,106 | 18 | <$5M | Research |
| Batson & Brown INC | Professional, Scientific, and Technical Services | $234,443 | $235,755 | 18 | <$5M | Research |
| Wigley & Culp, INC of Lucedale, Ms | Wholesale Trade | $229,300 | $230,626 | 22 | $5.7M | Research |
| The Bradshaw Agency, LLC | Finance and Insurance | $200,496 | $202,690 | 16 | $8.2M | Research |
| Qualified Fabrication INC | Manufacturing | $195,013 | $196,274 | 8 | <$5M | Research |
| Tmck Builders LLC | Manufacturing | $184,870 | $187,595 | 11 | <$5M | Research |