| Noxubee General Critical Access Hospital | Health Care and Social Assistance | $2,060,597 | $2,083,836 | 209 | $41.5M |  Research |
| Noxubee County Producers, Inc. | Agriculture, Forestry, Fishing and Hunting | $1,125,100 | $1,140,258 | 119 | $19.5M | Research |
| Barge Forest Products | Agriculture, Forestry, Fishing and Hunting | $895,700 | $900,452 | 79 | $8.1M | Research |
| Southern Seed & Feed, LLC | Agriculture, Forestry, Fishing and Hunting | $412,998 | $419,096 | 33 | <$5M | Research |
| Bogue Chitto Gin, Inc. | Agriculture, Forestry, Fishing and Hunting | $314,100 | $317,538 | 12 | <$5M | Research |
| Temsco INC | Retail Trade | $288,700 | $290,881 | 71 | $17.7M | Research |
| Trailboss Trailers | Manufacturing | $269,000 | $270,345 | 45 | $11.0M | Research |
| Trailboss Trailers Inc. | Manufacturing | $264,400 | $266,853 | 50 | $13.1M | Research |
| Bogue Chitto Gin Inc. | Agriculture, Forestry, Fishing and Hunting | $236,800 | $237,497 | 15 | <$5M | Research |
| East Mississippi Pole Company | Manufacturing | $210,700 | $211,929 | 22 | $21.8M | Research |
| Grayrock Trucking, Inc. | Transportation and Warehousing | $188,400 | $190,305 | 18 | <$5M | Research |
| Glory Revealed Mission | Other Services (except Public Administration) | $156,900 | $157,811 | 44 | $8.4M | Research |
| Penick Forest Products, Inc. | Manufacturing | $143,000 | $143,790 | 20 | $19.8M | Research |
| Macon City Drug Store INC | Retail Trade | $130,620 | $131,712 | 13 | <$5M | Research |
| Double D Carriers INC | Transportation and Warehousing | $126,400 | $127,931 | 17 | <$5M | Research |
| Macon Septic Systems Company INC | Administrative and Support and Waste Management | $115,800 | $116,646 | 8 | <$5M | Research |
| C&e Transportation INC | Transportation and Warehousing | $112,500 | $113,616 | 13 | <$5M | Research |
| Glory Revealed Mission | Other Services (except Public Administration) | $107,500 | $108,581 | 37 | $7.1M | Research |
| Lake Forest Ranch Inc. | Other Services (except Public Administration) | $104,000 | $104,714 | 80 | N/A | Research |
| Mississippi Welding & Machine LLC | Construction | $102,200 | $102,717 | 9 | <$5M | Research |
| Mississippi Welding & Machine, LLC | Construction | $102,200 | $103,074 | 9 | <$5M | Research |
| Triple J Equipment LLC | Transportation and Warehousing | $100,400 | $101,159 | 7 | <$5M | Research |
| Glass Tax LLC | Professional, Scientific, and Technical Services | $100,000 | $100,569 | 12 | <$5M | Research |
| Glass Tax | Professional, Scientific, and Technical Services | $95,832 | $96,636 | 10 | <$5M | Research |
| Lake Forest Ranch INC | Accommodation and Food Services | $89,600 | $90,668 | 11 | N/A | Research |