| At Home Care INC | Health Care and Social Assistance | $1,403,040 | $1,418,824 | 460 | $74.5M |  Research |
| Claiborne County Medical Center | Health Care and Social Assistance | $1,193,523 | $1,201,182 | 185 | N/A | Research |
| Claiborne County Medical Center | Health Care and Social Assistance | $1,193,523 | $1,201,579 | 165 | N/A | Research |
| Claiborne County Family Health Center | Health Care and Social Assistance | $396,143 | $398,443 | 29 | N/A | Research |
| J&j Ceramics | Arts, Entertainment, and Recreation | $225,000 | $18,868 | 10 | <$5M | Research |
| Thompson Transportation & Logistics LLC | Transportation and Warehousing | $140,827 | $142,513 | 10 | <$5M | Research |
| Farmers Cooperative, Aal | Retail Trade | $135,500 | $136,599 | 18 | <$5M | Research |
| Hudson's Grocery, INC | Retail Trade | $127,436 | $128,396 | 24 | $6.0M | Research |
| Save-Rite Discount Drugs, INC | Retail Trade | $116,166 | $117,424 | 13 | <$5M | Research |
| M&m Superstore, INC | Retail Trade | $90,300 | $90,915 | 20 | <$5M | Research |
| David M Headley, MD PA | Health Care and Social Assistance | $73,882 | $74,832 | 17 | $5.3M | Research |
| Small Town Pharmacy, LLC | Retail Trade | $73,728 | $74,650 | 6 | <$5M | Research |
| V&b International INC | Manufacturing | $61,073 | $61,536 | 13 | $12.9M | Research |
| V&b International, INC | Manufacturing | $61,073 | $61,551 | 14 | $13.9M | Research |
| Heavenly Angels Daycare INC | Health Care and Social Assistance | $49,914 | $50,255 | 3 | <$5M | Research |
| Quality Rehab, INC | Health Care and Social Assistance | $44,717 | $45,013 | 6 | <$5M | Research |
| Quality Rehab INC | Health Care and Social Assistance | $44,717 | $44,922 | 4 | <$5M | Research |
| King's Psychiatric Service LLC | Health Care and Social Assistance | $37,530 | $38,019 | 2 | <$5M | Research |
| Claiborne Car Care, INC | Retail Trade | $36,317 | $36,555 | 5 | <$5M | Research |
| Bayou Pierre Farms | Agriculture, Forestry, Fishing and Hunting | $33,047 | $47,209 | 11 | <$5M | Research |
| Nicks's One Stop of Port Gibson, LLC | Retail Trade | $32,157 | $32,481 | 5 | <$5M | Research |
| Little Kids University,inc | Health Care and Social Assistance | $30,064 | $30,507 | 8 | <$5M | Research |
| Little Kids Universityinc | Health Care and Social Assistance | $29,998 | $30,191 | 8 | <$5M | Research |
| Tesia Lewis | Accommodation and Food Services | $29,166 | $29,233 | 1 | <$5M | Research |
| Benjamin Apollos | Arts, Entertainment, and Recreation | $27,040 | $27,121 | 1 | <$5M | Research |