| Perry County General Hospital LLC | Health Care and Social Assistance | $621,040 | $624,341 | 69 | $21.7M |  Research |
| Perry County General Hospital, | Health Care and Social Assistance | $621,000 | $625,032 | 65 | $12.9M | Research |
| Community Development Inc. | Health Care and Social Assistance | $551,097 | $558,691 | 144 | N/A | Research |
| Community Development INC | Health Care and Social Assistance | $547,000 | $556,666 | 140 | N/A | Research |
| Walley Investments LLC | Accommodation and Food Services | $403,651 | $407,800 | 75 | $13.3M | Research |
| Henderson Lumber LLC | Manufacturing | $395,000 | $400,014 | 39 | $38.7M | Research |
| Glen Henderson Logging and Trucking Co. Inc. | Agriculture, Forestry, Fishing and Hunting | $363,200 | $367,982 | 25 | <$5M | Research |
| Deep South Machine Works and Hydraulics LLC | Construction | $294,203 | $296,966 | 29 | $9.9M | Research |
| Deep South Machine Works and Hyraulics LLC | Construction | $291,700 | $295,217 | 29 | $9.9M | Research |
| Walley Investments, LLC | Finance and Insurance | $289,800 | $293,575 | 75 | $38.5M | Research |
| A-1 Sealing INC | Construction | $285,700 | $228,374 | 17 | $5.3M | Research |
| Southeastern Petroleum INC | Retail Trade | $234,000 | $235,586 | 48 | $12.0M | Research |
| A-1 Sealing Inc. | Construction | $212,925 | $215,719 | 14 | <$5M | Research |
| Henderson Timber Felling, Inc. | Agriculture, Forestry, Fishing and Hunting | $183,353 | $185,335 | 24 | <$5M | Research |
| James Enterprises INC | Transportation and Warehousing | $142,474 | $143,493 | 17 | <$5M | Research |
| Tucker Thinning, Inc. | Agriculture, Forestry, Fishing and Hunting | $124,185 | $124,934 | 11 | <$5M | Research |
| Jerold Henderson Logging, INC | Agriculture, Forestry, Fishing and Hunting | $115,242 | $116,284 | 10 | <$5M | Research |
| Red Oaks Farm | Agriculture, Forestry, Fishing and Hunting | $114,200 | $114,860 | 8 | <$5M | Research |
| James Enterprises, INC | Transportation and Warehousing | $113,000 | $113,678 | 17 | <$5M | Research |
| Tim's Inc. | Retail Trade | $91,200 | $92,145 | 17 | $5.7M | Research |
| Strickland's Cash and Save Discount Pharmacy Inc. | Wholesale Trade | $84,096 | $84,619 | 8 | <$5M | Research |
| Two River's Outdoors, Farm and Home Center, LLC | Retail Trade | $81,900 | $82,463 | 18 | <$5M | Research |
| Tucker Thinning Inc. | Agriculture, Forestry, Fishing and Hunting | $76,920 | $78,159 | 10 | <$5M | Research |
| Ward's Fast Food of Richton, INC | Accommodation and Food Services | $72,700 | $73,457 | 21 | <$5M | Research |
| Jcm Timber LLC | Agriculture, Forestry, Fishing and Hunting | $71,896 | $72,195 | 9 | <$5M | Research |