| Harrison County Community Hospital District | Health Care and Social Assistance | $2,967,811 | $2,999,360 | 209 | N/A |  Research |
| Pettijohn Auto Center, Inc. | Retail Trade | $425,738 | $429,120 | 57 | $14.4M | Research |
| Central Programs, Inc. | Wholesale Trade | $347,700 | $350,539 | 62 | $16.0M | Research |
| Central Programs Inc. | Wholesale Trade | $347,700 | $349,786 | 42 | $10.8M | Research |
| N and R Crestview LLC | Health Care and Social Assistance | $332,900 | $336,740 | 99 | $16.8M | Research |
| Nail Excavating LLC | Construction | $268,377 | $269,951 | 25 | $7.7M | Research |
| Toot Toot Restaurant LLC | Accommodation and Food Services | $250,897 | $252,681 | 38 | $6.7M | Research |
| Toot Toot Restaurant LLC | Accommodation and Food Services | $185,000 | $186,043 | 34 | $6.0M | Research |
| Harrison County Handicapped Group Home Corporation | Health Care and Social Assistance | $170,023 | $170,991 | 27 | N/A | Research |
| First Call Storm Removal, LLC | Health Care and Social Assistance | $119,890 | $120,979 | 17 | <$5M | Research |
| First Call Storm Removal, LLC | Health Care and Social Assistance | $119,890 | $121,258 | 11 | <$5M | Research |
| Harrison County Sheltered Workshop Association | Health Care and Social Assistance | $117,337 | $117,741 | 61 | N/A | Research |
| Harrison County Sheltered Workshop Inc. | Health Care and Social Assistance | $114,113 | $114,807 | 70 | N/A | Research |
| Roberson Funeral Homes, Inc. | Other Services (except Public Administration) | $108,390 | $108,990 | 14 | <$5M | Research |
| Bethany Building Center INC | Retail Trade | $92,478 | $93,293 | 8 | <$5M | Research |
| Mccall Family Dentistry | Health Care and Social Assistance | $81,878 | $82,400 | 6 | <$5M | Research |
| Willard Darby Jr. | Agriculture, Forestry, Fishing and Hunting | $73,172 | $73,436 | 9 | <$5M | Research |
| Dawn Til Dusk Disaster Relief LLC | Construction | $71,768 | $72,463 | 7 | <$5M | Research |
| Dawn Til Dusk Disaster Relief LLC | Health Care and Social Assistance | $71,767 | $72,644 | 7 | <$5M | Research |
| Shining LLC | Accommodation and Food Services | $69,058 | $69,355 | 15 | <$5M | Research |
| Wieland Hauling INC | Transportation and Warehousing | $66,247 | $66,488 | 14 | <$5M | Research |
| Shining LLC | Accommodation and Food Services | $58,200 | $58,604 | 6 | <$5M | Research |
| O'neil's Home Furnishing & Floor Covering | Retail Trade | $47,400 | $47,636 | 6 | <$5M | Research |
| Rardon Heating & Electric Inc. | Construction | $47,053 | $47,250 | 3 | <$5M | Research |
| Green Hills Insurance LLC | Finance and Insurance | $45,744 | $45,853 | 5 | <$5M | Research |