| American Nursing & Rehab, LLC | Health Care and Social Assistance | $524,300 | $533,548 | 103 | $17.5M |  Research |
| Valley Minerals, LLC | Manufacturing | $432,400 | $435,139 | 33 | $32.7M | Research |
| Reliable Home Care, INC | Health Care and Social Assistance | $384,402 | $387,381 | 189 | $32.4M | Research |
| Gws Contractors Inc. | Construction | $325,000 | $326,192 | 20 | $6.3M | Research |
| Brm, LLC | Manufacturing | $296,500 | $298,345 | 21 | $5.1M | Research |
| Ozark Ltc Rx, LLC | Retail Trade | $285,700 | $288,087 | 35 | $6.1M | Research |
| Autocenters of Bonne Terre LLC | Retail Trade | $261,210 | $263,184 | 13 | <$5M | Research |
| Autocenters of Bonne Terre LLC | Retail Trade | $261,210 | $262,799 | 13 | <$5M | Research |
| J.a.k. Properties, Inc. | Health Care and Social Assistance | $258,579 | $260,577 | 58 | $9.9M | Research |
| Gws Contractors, INC | Construction | $255,900 | $326,607 | 20 | <$5M | Research |
| Dean Frink Transportation | Transportation and Warehousing | $232,685 | $236,217 | 23 | $5.2M | Research |
| Midwest Heallth Group Convenient Care, LLC | Health Care and Social Assistance | $232,192 | $233,452 | 31 | $9.7M | Research |
| Midwest Heallth Group Convenient Care, LLC | Health Care and Social Assistance | $232,192 | $234,183 | 22 | $6.9M | Research |
| Can Stockers, Inc. | Retail Trade | $211,145 | $212,793 | 56 | $14.0M | Research |
| Woodland Operations and Maintenance, LLC | Agriculture, Forestry, Fishing and Hunting | $201,327 | $203,284 | 25 | <$5M | Research |
| C.z. Boyer and Son Inc. | Other Services (except Public Administration) | $172,330 | $174,960 | 22 | <$5M | Research |
| Griffin Automotive Design, LLC | Other Services (except Public Administration) | $160,752 | $162,289 | 20 | <$5M | Research |
| Blackwell Motors Inc. | Retail Trade | $148,600 | $149,166 | 13 | <$5M | Research |
| Bonne Terre Meat Company | Wholesale Trade | $126,662 | $127,582 | 14 | <$5M | Research |
| Blackwell Motors Inc. | Retail Trade | $124,202 | $126,359 | 15 | <$5M | Research |
| Terre Du Lac Association INC | Other Services (except Public Administration) | $118,212 | $118,971 | 12 | N/A | Research |
| Heimburget Construction, INC | Construction | $116,457 | $117,140 | 10 | $11.4M | Research |
| Homestead Restaurant Inc. | Accommodation and Food Services | $109,627 | $110,449 | 18 | <$5M | Research |
| Jb Restaurant Investments INC | Accommodation and Food Services | $98,892 | $99,826 | 35 | $6.2M | Research |
| Pizza 101 South LLC | Accommodation and Food Services | $98,455 | $99,229 | 18 | <$5M | Research |