| White & Associates Home Assistance INC | Finance and Insurance | $981,300 | $990,813 | 316 | $162.4M | AI Deep Dive |
| Trowbridge Enterprises, LLC | Health Care and Social Assistance | $403,700 | $406,290 | 79 | $13.5M | AI Deep Dive |
| Guardian Angels in Home Services | Health Care and Social Assistance | $362,900 | $365,702 | 130 | $22.1M | AI Deep Dive |
| Cmv in Home Assistance, INC | Health Care and Social Assistance | $337,200 | $340,350 | 85 | $14.6M | AI Deep Dive |
| Guardian Angels in Home Services | Health Care and Social Assistance | $336,370 | $338,071 | 86 | $14.7M | AI Deep Dive |
| Wepfer Marine of Caruthersville, LLC | Transportation and Warehousing | $279,700 | $282,660 | 23 | <$5M | AI Deep Dive |
| Don Medlin, Co | Retail Trade | $235,427 | $236,859 | 22 | $5.7M | AI Deep Dive |
| Don Medlin Co. | Retail Trade | $235,427 | $236,336 | 40 | $10.4M | AI Deep Dive |
| Car Mac's Mini Mart | Wholesale Trade | $168,700 | $170,336 | 26 | $6.7M | AI Deep Dive |
| Lee M. & Elizabeth J. Dorroh | Agriculture, Forestry, Fishing and Hunting | $154,698 | $155,813 | 15 | <$5M | AI Deep Dive |
| Prescription Drug Store LLC | Retail Trade | $153,400 | $154,414 | 16 | <$5M | AI Deep Dive |
| Caruthersville Gin, Inc. | Agriculture, Forestry, Fishing and Hunting | $151,694 | $152,612 | 10 | <$5M | AI Deep Dive |
| Caruthersville Gin Inc. | Agriculture, Forestry, Fishing and Hunting | $151,694 | $152,409 | 8 | <$5M | AI Deep Dive |
| Ddab Farms | Agriculture, Forestry, Fishing and Hunting | $149,505 | $149,996 | 16 | <$5M | AI Deep Dive |
| Prescription In-Home Services, LLC | Health Care and Social Assistance | $122,200 | $123,004 | 18 | <$5M | AI Deep Dive |
| Michael Bernard | Agriculture, Forestry, Fishing and Hunting | $115,419 | $116,487 | 11 | <$5M | AI Deep Dive |
| T & K Sullivan Auto & Tire LLC | Other Services (except Public Administration) | $111,600 | $112,254 | 12 | <$5M | AI Deep Dive |
| Grizzly Jig Company LLC | Retail Trade | $101,100 | $101,676 | 15 | <$5M | AI Deep Dive |
| Always First Consumer Direct Services, LLC | Health Care and Social Assistance | $90,700 | $91,355 | 41 | $7.0M | AI Deep Dive |
| Tipton Farms INC | Agriculture, Forestry, Fishing and Hunting | $90,255 | $90,685 | 12 | <$5M | AI Deep Dive |
| Sonic Drive-In of Caruthersville | Accommodation and Food Services | $88,700 | $89,304 | 30 | $5.3M | AI Deep Dive |
| Riggs Lawn & Landscaping | Administrative and Support and Waste Management | $86,200 | $86,839 | 8 | <$5M | AI Deep Dive |
| Bishop Home Care, LLC | Health Care and Social Assistance | $84,200 | $84,894 | 48 | $8.2M | AI Deep Dive |
| Thomas, Speight and Noble - Caruthersville | Professional, Scientific, and Technical Services | $80,174 | $80,651 | 6 | <$5M | AI Deep Dive |
| United Termite & Pest Control Co. | Administrative and Support and Waste Management | $79,700 | $80,200 | 8 | <$5M | AI Deep Dive |