| Edwards Transportation Company INC | Transportation and Warehousing | $668,700 | $672,564 | 64 | $12.9M |  AI Deep Dive |
| Bootheel Tractor Parts, Inc. | Retail Trade | $415,300 | $418,034 | 25 | $5.2M | AI Deep Dive |
| Quality Care Services, LLC | Health Care and Social Assistance | $363,469 | $366,327 | 104 | $17.8M | AI Deep Dive |
| Laplant Transport, Inc. | Transportation and Warehousing | $320,000 | $322,373 | 38 | $7.7M | AI Deep Dive |
| Laplant Transport LLC | Transportation and Warehousing | $312,245 | $314,396 | 48 | $9.7M | AI Deep Dive |
| Holy Smokes, LLC | Accommodation and Food Services | $163,700 | $164,791 | 25 | <$5M | AI Deep Dive |
| Stanley Muffler Co. INC | Manufacturing | $153,400 | $154,342 | 21 | $5.5M | AI Deep Dive |
| Tasters Restaurants, Inc. | Accommodation and Food Services | $152,905 | $153,750 | 42 | $7.5M | AI Deep Dive |
| Brewer Drugs, Inc. | Retail Trade | $133,100 | $133,924 | 13 | <$5M | AI Deep Dive |
| N and R of East Prairie, INC | Health Care and Social Assistance | $130,200 | $131,730 | 41 | $7.0M | AI Deep Dive |
| Mrm Farms | Agriculture, Forestry, Fishing and Hunting | $123,160 | $124,216 | 17 | <$5M | AI Deep Dive |
| M & M Ag Investments | Real Estate and Rental and Leasing | $80,100 | $80,647 | 8 | <$5M | AI Deep Dive |
| Wolf Island Farms INC | Agriculture, Forestry, Fishing and Hunting | $76,800 | $77,164 | 9 | <$5M | AI Deep Dive |
| L.d. Davis Lumber & Hardware Co | Retail Trade | $74,189 | $74,643 | 15 | <$5M | AI Deep Dive |
| Wolf Island Farms INC | Agriculture, Forestry, Fishing and Hunting | $67,300 | $67,700 | 8 | <$5M | AI Deep Dive |
| Yellow Gold LLC | Construction | $64,375 | $64,752 | 7 | <$5M | AI Deep Dive |
| K & J Enterprises of Southeast Missouri Inc. | Accommodation and Food Services | $52,700 | $53,063 | 17 | <$5M | AI Deep Dive |
| Summer Cox | Construction | $44,638 | $44,823 | 7 | <$5M | AI Deep Dive |
| Rivers Edge Trucking LLC | Transportation and Warehousing | $41,343 | $41,543 | 3 | <$5M | AI Deep Dive |
| William Dill | Agriculture, Forestry, Fishing and Hunting | $38,677 | $38,862 | 6 | <$5M | AI Deep Dive |
| Keene Welding LLC | Manufacturing | $38,367 | $38,590 | 3 | <$5M | AI Deep Dive |
| Big River Excavation LLC | Construction | $37,500 | $37,729 | 5 | <$5M | AI Deep Dive |
| Rushridge Ag LLC | Agriculture, Forestry, Fishing and Hunting | $36,050 | $36,283 | 5 | <$5M | AI Deep Dive |
| Main Street Rx LLC | Retail Trade | $36,000 | $36,225 | 4 | <$5M | AI Deep Dive |
| Ernest Minehart | Agriculture, Forestry, Fishing and Hunting | $35,600 | $35,736 | 4 | <$5M | AI Deep Dive |