| Pemiscot County Memorial Hospital | Health Care and Social Assistance | $2,811,243 | $2,527,192 | 289 | N/A |  Research |
| Pemiscot County Memorial Hospital | Health Care and Social Assistance | $2,000,000 | $2,014,849 | 259 | N/A | Research |
| Crawford Oil Company, INC | Retail Trade | $674,800 | $680,348 | 127 | $42.5M | Research |
| Mid-Continent Aircraft Corporation | Agriculture, Forestry, Fishing and Hunting | $464,485 | $467,427 | 50 | <$5M | Research |
| Mid-Continent Aircraft Corporation | Agriculture, Forestry, Fishing and Hunting | $445,700 | $448,968 | 47 | <$5M | Research |
| Tomlin Trucking LLC | Transportation and Warehousing | $405,030 | $406,883 | 26 | $5.2M | Research |
| Cotoneaster, INC | Health Care and Social Assistance | $339,700 | $342,193 | 69 | $11.8M | Research |
| Tomlin Trucking, LLC | Transportation and Warehousing | $337,683 | $339,893 | 28 | $5.6M | Research |
| Rayetta Smith | Health Care and Social Assistance | $251,717 | $252,962 | 149 | $25.5M | Research |
| Air-Aids, INC | Agriculture, Forestry, Fishing and Hunting | $193,300 | $194,718 | 19 | <$5M | Research |
| Tomlin Trucking and Brokerage INC | Transportation and Warehousing | $174,510 | $175,661 | 11 | <$5M | Research |
| R & P Transport LLC | Retail Trade | $150,600 | $151,750 | 11 | <$5M | Research |
| Tim Gardner Groceries, LLC | Retail Trade | $148,436 | $149,546 | 10 | <$5M | Research |
| El Patio Hayti, L.l.c. | Accommodation and Food Services | $120,200 | $121,502 | 15 | <$5M | Research |
| Southeast Specialties LLC | Health Care and Social Assistance | $96,707 | $97,209 | 25 | <$5M | Research |
| Pemiscot Progressive Industrie | Other Services (except Public Administration) | $87,950 | $88,401 | 25 | <$5M | Research |
| Extended Home Care, Inc. | Health Care and Social Assistance | $87,400 | $88,024 | 27 | <$5M | Research |
| Extended Home Care Inc. | Health Care and Social Assistance | $87,400 | $87,827 | 22 | <$5M | Research |
| Southeast Specialties, LLC | Health Care and Social Assistance | $81,870 | $82,536 | 37 | $6.3M | Research |
| Jimmie M. Morgan | Retail Trade | $59,244 | $59,653 | 28 | $9.4M | Research |
| Natural Biodiesel Plant LLC | Manufacturing | $57,700 | $57,959 | 3 | <$5M | Research |
| Natural Biodiesel Plant LLC | Manufacturing | $57,700 | $58,242 | 5 | <$5M | Research |
| Donna Ring Corporation | Retail Trade | $55,375 | $55,737 | 4 | <$5M | Research |
| Ace Wrecker & Repair LLC | Other Services (except Public Administration) | $50,232 | $50,534 | 4 | <$5M | Research |
| Dwayne Clark, PC | Professional, Scientific, and Technical Services | $48,800 | $49,180 | 4 | <$5M | Research |