| Baker Implement Company | Wholesale Trade | $1,948,637 | $1,964,984 | 145 | $44.4M |  Research |
| Visiting Nurse Association of Southeast Missouri, Inc. | Health Care and Social Assistance | $1,728,700 | $1,749,060 | 214 | N/A | Research |
| Glen Sain Chevrolet-Buick-Cadillac-Gmc INC | Retail Trade | $299,400 | $301,295 | 32 | $8.1M | Research |
| Ark-Mo Well Drilling and Services Co, INC | Construction | $287,330 | $289,062 | 19 | $6.5M | Research |
| Ark-Mo Well Drilling and Service Co | Construction | $287,329 | $290,290 | 19 | $6.5M | Research |
| Skeeter Kell Sporting Goods Inc. | Retail Trade | $285,400 | $287,636 | 38 | $8.9M | Research |
| Skeeter Kell Sporting Goods | Retail Trade | $264,600 | $288,111 | 40 | $9.4M | Research |
| Graves Kennett Gin Co. Inc. | Agriculture, Forestry, Fishing and Hunting | $197,608 | $198,707 | 14 | <$5M | Research |
| Bradley Distributing Co., Inc. | Wholesale Trade | $178,860 | $180,072 | 15 | <$5M | Research |
| Harris Pharmacy, LLC | Retail Trade | $177,655 | $178,691 | 17 | <$5M | Research |
| Mcpherson Medical and Diagnostic, LLC | Health Care and Social Assistance | $161,513 | $162,522 | 23 | $7.2M | Research |
| Brown Brothers Farms | Agriculture, Forestry, Fishing and Hunting | $151,848 | $153,218 | 14 | <$5M | Research |
| Dalton Petroleum INC | Retail Trade | $138,400 | $139,984 | 32 | $10.7M | Research |
| Burcham Dental Arts Clinic INC | Health Care and Social Assistance | $138,027 | $138,980 | 7 | <$5M | Research |
| Burcham Dental Arts Clinic, Inc. | Health Care and Social Assistance | $138,027 | $139,687 | 7 | <$5M | Research |
| Scherer, Grayham, and Clark, LLP | Professional, Scientific, and Technical Services | $133,163 | $134,235 | 12 | <$5M | Research |
| Hope@home LLC | Health Care and Social Assistance | $121,200 | $122,227 | 27 | <$5M | Research |
| Sonic Drive-In of Kennett INC | Accommodation and Food Services | $120,600 | $121,421 | 37 | $6.6M | Research |
| Kennett Pediatrics and Adolescent Medicine LLC | Health Care and Social Assistance | $113,327 | $114,123 | 10 | <$5M | Research |
| Crow, Reynolds, Shetley, Mcvey & Scherer LLP | Professional, Scientific, and Technical Services | $106,670 | $107,292 | 8 | <$5M | Research |
| Mi Ranchito of Missouri Inc. | Accommodation and Food Services | $100,949 | $101,431 | 17 | <$5M | Research |
| Semo Drugs of Kennett INC | Retail Trade | $99,700 | $100,339 | 14 | <$5M | Research |
| Grecian Steak House of Kennett Inc. | Accommodation and Food Services | $98,041 | $98,766 | 20 | <$5M | Research |
| Marc Ross Trucking Llc. | Transportation and Warehousing | $88,485 | $89,099 | 6 | <$5M | Research |
| Kennett Irrigation & Equipment Company | Utilities | $82,972 | $83,442 | 9 | N/A | Research |