| Pike County Memorial Hospital | Health Care and Social Assistance | $1,876,800 | $1,887,804 | 192 | N/A |  Research |
| Abel Oil Co., Inc. | Wholesale Trade | $1,480,000 | $1,491,717 | 186 | $47.9M | Research |
| Stark Bro's Nurseries & Orchards Co. | Retail Trade | $940,150 | $948,220 | 61 | $12.6M | Research |
| Lacrosse Lumber Company | Retail Trade | $929,692 | $937,284 | 96 | $19.8M | Research |
| Twin Pike Family Ymca | Arts, Entertainment, and Recreation | $173,200 | $174,552 | 80 | N/A | Research |
| Mash Ii, INC | Retail Trade | $126,200 | $127,061 | 14 | <$5M | Research |
| Dewey Holding Company Inc. | Manufacturing | $115,586 | $116,485 | 12 | $11.9M | Research |
| Pike Grain Company INC | Agriculture, Forestry, Fishing and Hunting | $109,665 | $110,125 | 15 | <$5M | Research |
| Pike Grain Company INC | Agriculture, Forestry, Fishing and Hunting | $98,020 | $98,709 | 13 | <$5M | Research |
| Ray's Construction LLC | Construction | $94,352 | $94,871 | 6 | <$5M | Research |
| Lynn's Heritage House, INC | Health Care and Social Assistance | $92,122 | $92,649 | 23 | <$5M | Research |
| Brown's Auto Body Services Inc. | Other Services (except Public Administration) | $91,474 | $91,968 | 12 | <$5M | Research |
| The E. Rex Bradley Law Firm PC | Professional, Scientific, and Technical Services | $56,200 | $56,764 | 6 | <$5M | Research |
| The E. Rex Bradley Law Firm | Professional, Scientific, and Technical Services | $56,200 | $56,536 | 6 | <$5M | Research |
| K.c.'s Place, L.l.c. | Accommodation and Food Services | $46,479 | $46,767 | 8 | <$5M | Research |
| Lael Trucking | Transportation and Warehousing | $44,852 | $45,317 | 15 | <$5M | Research |
| Gloria Dei Academy | Educational Services | $40,660 | $40,898 | 12 | N/A | Research |
| Gloria Dei Academy | Educational Services | $40,660 | $40,919 | 11 | N/A | Research |
| C-M-C Distributing and Manufacturing | Wholesale Trade | $36,373 | $36,586 | 5 | <$5M | Research |
| Twin Valley Transport, LLC | Transportation and Warehousing | $35,390 | $35,673 | 4 | <$5M | Research |
| Happy Krupa INC | Accommodation and Food Services | $35,300 | $35,597 | 9 | <$5M | Research |
| Frank T. Thomalla, III DDS & Associates, Inc. | Health Care and Social Assistance | $35,280 | $35,461 | 4 | <$5M | Research |
| Collier Funeral Homes | Other Services (except Public Administration) | $34,468 | $34,740 | 2 | <$5M | Research |
| Louisiana Dos Primos, LLC | Accommodation and Food Services | $32,500 | $32,897 | 8 | <$5M | Research |
| Dogood Taverns LLC | Accommodation and Food Services | $29,750 | $29,870 | 5 | <$5M | Research |