| Robinson Mechanical Contractors, INC | Construction | $6,982,700 | $7,057,764 | 434 | $137.3M |  Research |
| Perry County Health System | Health Care and Social Assistance | $5,289,710 | $5,353,921 | 366 | N/A | Research |
| Semco Distributing, INC | Wholesale Trade | $1,526,494 | $1,537,900 | 137 | $42.0M | Research |
| Richardet Floor Covering Co. Inc. | Construction | $1,415,330 | $1,426,142 | 76 | $25.9M | Research |
| Earthworks, Inc. | Mining, Quarrying, and Oil and Gas Extraction | $1,414,342 | $1,426,742 | 118 | $7.2M | Research |
| Richardet Floor Covering Co., Inc. | Construction | $1,378,572 | $1,389,945 | 88 | $33.0M | Research |
| Independence Health System INC | Health Care and Social Assistance | $819,500 | $826,281 | 153 | N/A | Research |
| Association of the Miraculous Medal | Other Services (except Public Administration) | $741,500 | $745,441 | 70 | N/A | Research |
| The Rozier Mercantile Company | Retail Trade | $741,200 | $746,175 | 175 | $43.7M | Research |
| Rollet Bros Trucking Company INC | Transportation and Warehousing | $723,500 | $728,218 | 65 | $14.8M | Research |
| Mdr Holdings LLC | Transportation and Warehousing | $568,500 | $572,160 | 28 | $6.4M | Research |
| St. Vincent De Paul Catholic Church, Perryville | Other Services (except Public Administration) | $567,700 | $570,966 | 83 | N/A | Research |
| Zoellner Construction Co, Inc. | Construction | $477,500 | $480,184 | 31 | $35.3M | Research |
| Zoellner Construction Co INC | Construction | $477,360 | $479,113 | 32 | $36.5M | Research |
| Rmc, LLC | Manufacturing | $453,700 | $456,485 | 46 | $45.6M | Research |
| Rbt INC | Transportation and Warehousing | $417,200 | $420,080 | 28 | $6.4M | Research |
| Tnt Plastics INC | Manufacturing | $400,800 | $405,247 | 35 | $34.7M | Research |
| Zahner & Associates, Inc. | Professional, Scientific, and Technical Services | $368,875 | $370,935 | 33 | $6.7M | Research |
| Davis Farm Supplies INC | Wholesale Trade | $356,550 | $357,927 | 32 | $9.8M | Research |
| Davis Farm Supplies, Inc. | Retail Trade | $356,500 | $358,532 | 31 | $6.4M | Research |
| Keller Motors, Inc. | Retail Trade | $350,700 | $355,084 | 34 | $8.6M | Research |
| Schemel Companies, Inc. | Construction | $348,000 | $350,012 | 23 | $7.0M | Research |
| The Estates of Perryville, LLC | Health Care and Social Assistance | $326,000 | $328,996 | 88 | $15.0M | Research |
| Perryville Family Care Clinic Professional Corporation | Health Care and Social Assistance | $303,000 | $306,279 | 12 | <$5M | Research |
| Mary Jane Burgers & Brew LLC | Accommodation and Food Services | $285,282 | $286,892 | 47 | $8.3M | Research |