| Leo O'laughlin INC | Transportation and Warehousing | $468,900 | $471,909 | 34 | $9.1M |  Research |
| Spectrum Partners, LLC | Health Care and Social Assistance | $178,890 | $179,856 | 34 | $5.8M | Research |
| Boarmax INC | Agriculture, Forestry, Fishing and Hunting | $167,017 | $168,018 | 45 | <$5M | Research |
| Boarmax INC | Agriculture, Forestry, Fishing and Hunting | $166,101 | $166,902 | 47 | $7.7M | Research |
| Schwada Builders INC | Construction | $157,848 | $158,817 | 20 | $22.8M | Research |
| Ricketts Farm Service of Shelbina INC | Wholesale Trade | $151,800 | $152,795 | 20 | $5.1M | Research |
| Greening Eagan Hayes Funeral Home INC | Other Services (except Public Administration) | $146,185 | $147,198 | 14 | <$5M | Research |
| Schwada Builders INC | Construction | $143,805 | $144,514 | 12 | $13.7M | Research |
| 12-D Construction LLC | Construction | $100,885 | $101,620 | 20 | $22.8M | Research |
| Passion for Pigs Veterinary Service LLC | Retail Trade | $89,469 | $90,047 | 10 | <$5M | Research |
| Northeast Diesel Service of Missouri, Inc. | Other Services (except Public Administration) | $87,989 | $88,516 | 11 | <$5M | Research |
| Fohey Farms of Missouri Inc. | Agriculture, Forestry, Fishing and Hunting | $76,324 | $76,588 | 11 | <$5M | Research |
| Ani-Tek Group LLC | Agriculture, Forestry, Fishing and Hunting | $67,707 | $67,870 | 4 | <$5M | Research |
| Hines Performance Parts LLC | Retail Trade | $67,500 | $67,922 | 8 | <$5M | Research |
| Shelbina Pharamcy, L.l.c. | Retail Trade | $62,157 | $62,870 | 3 | <$5M | Research |
| Bk Concrete | Construction | $58,141 | $58,608 | 17 | <$5M | Research |
| 4rd, LLC | Other Services (except Public Administration) | $49,606 | $49,861 | 9 | <$5M | Research |
| First American Security Agency Inc. | Finance and Insurance | $42,900 | $43,224 | 5 | <$5M | Research |
| Shelby County Senior Citizens Association INC | Health Care and Social Assistance | $37,732 | $37,936 | 19 | N/A | Research |
| Wilcox and Williams LLC | Professional, Scientific, and Technical Services | $37,209 | $37,402 | 4 | <$5M | Research |
| Wilt Truck and Welding LLC | Other Services (except Public Administration) | $36,576 | $36,748 | 4 | <$5M | Research |
| Latchford Family Farms | Agriculture, Forestry, Fishing and Hunting | $35,538 | $35,676 | 4 | <$5M | Research |
| Northeast Veterinary Service INC | Professional, Scientific, and Technical Services | $34,291 | $34,512 | 5 | <$5M | Research |
| Red Barn Veterinary Services | Professional, Scientific, and Technical Services | $33,774 | $33,898 | 5 | <$5M | Research |
| Tims Home Center LLC | Retail Trade | $33,622 | $33,810 | 5 | <$5M | Research |