| Novel Iron Works INC | Manufacturing | $1,217,181 | $1,229,150 | 129 | $33.8M |  Research |
| Novel Iron Works INC | Manufacturing | $1,157,300 | $1,166,108 | 97 | $23.7M | Research |
| Medmatica Consulting Associates INC | Professional, Scientific, and Technical Services | $678,695 | $680,368 | 32 | <$5M | Research |
| Rose Steel INC | Construction | $597,156 | $603,144 | 129 | $40.0M | Research |
| Rose Steel INC | Construction | $547,100 | $551,264 | 42 | $9.7M | Research |
| Jake Kaplan%27s of Portsmouth Inc. | Retail Trade | $521,585 | $527,974 | 37 | $9.3M | Research |
| Seacoast Volkswagen, Inc. | Retail Trade | $481,700 | $485,273 | 39 | $9.8M | Research |
| Mechanical Air of New England | Construction | $368,300 | $372,629 | 26 | $8.2M | Research |
| Portsmouth Country Club | Arts, Entertainment, and Recreation | $309,900 | $311,518 | 100 | $14.0M | Research |
| Bethany Christian Church | Other Services (except Public Administration) | $269,487 | $271,860 | 31 | N/A | Research |
| Radm Donuts LLC | Accommodation and Food Services | $237,600 | $240,406 | 45 | $8.0M | Research |
| Advanced Concrete Technologies, Inc. | Manufacturing | $227,580 | $230,014 | 10 | <$5M | Research |
| Hart Plumbing & Heating, Inc. | Construction | $225,000 | $228,025 | 14 | <$5M | Research |
| Tidewatch Partners, LLC | Professional, Scientific, and Technical Services | $220,348 | $222,484 | 13 | <$5M | Research |
| Rumbletree INC | Professional, Scientific, and Technical Services | $216,007 | $217,291 | 15 | <$5M | Research |
| Axl, Inc. | Transportation and Warehousing | $208,275 | $210,878 | 16 | <$5M | Research |
| Tiny Bully, LLC F K a Microarts, LLC | Professional, Scientific, and Technical Services | $203,100 | $204,708 | 11 | <$5M | Research |
| Jdl Building & Remodeling of New England, LLC | Construction | $173,450 | $175,820 | 14 | <$5M | Research |
| Drogold LLC | Construction | $168,017 | $168,661 | 12 | <$5M | Research |
| Drogold, LLC | Administrative and Support and Waste Management | $168,000 | $169,241 | 10 | <$5M | Research |
| Silver Street Donuts LLC | Accommodation and Food Services | $165,676 | $167,079 | 20 | <$5M | Research |
| Jdl Building & Remodeling of New England | Construction | $149,000 | $151,111 | 14 | <$5M | Research |
| Perry Plumbing & Heating, Inc. | Construction | $147,015 | $147,945 | 8 | <$5M | Research |
| Alternate Transit Advertising INC | Professional, Scientific, and Technical Services | $140,000 | $141,015 | 10 | <$5M | Research |
| Alternate Transit Advertising Inc. | Professional, Scientific, and Technical Services | $133,450 | $133,987 | 10 | <$5M | Research |