| Jebediah S. Christy, D.d.s., P.c. | Health Care and Social Assistance | $3,968,728 | $3,466,218 | 277 | $64.2M |  Research |
| Wks INC | Health Care and Social Assistance | $2,145,300 | $2,173,395 | 468 | $75.8M | Research |
| Monadnock Developmental Services | Health Care and Social Assistance | $1,577,200 | $1,590,077 | 250 | N/A | Research |
| Vna at Hcs, Inc. | Health Care and Social Assistance | $1,496,000 | $1,513,829 | 136 | N/A | Research |
| The Filtrine Manufacturing Company, | Manufacturing | $1,449,400 | $1,461,750 | 89 | $23.3M | Research |
| People's Linen Service LLC | Other Services (except Public Administration) | $1,415,050 | $1,422,067 | 121 | $23.1M | Research |
| People's Linen Service, LLC | Other Services (except Public Administration) | $1,415,000 | $1,422,975 | 162 | $30.9M | Research |
| Bagel Works, Inc. | Accommodation and Food Services | $1,009,935 | $1,013,863 | 78 | $13.8M | Research |
| Cedarcrest, Inc. | Health Care and Social Assistance | $947,500 | $958,143 | 113 | N/A | Research |
| Hamshaw Lumber INC | Wholesale Trade | $909,100 | $917,643 | 122 | $37.4M | Research |
| The Prospect-Woodward Home | Health Care and Social Assistance | $840,200 | $849,062 | 112 | N/A | Research |
| Fairfields Cadillac Buick Gmc INC | Retail Trade | $828,100 | $837,016 | 59 | $14.9M | Research |
| Cactus Flower Employment Services INC | Administrative and Support and Waste Management | $820,000 | $827,526 | 160 | $25.2M | Research |
| Monadnock Community Market Coop Inc. | Wholesale Trade | $701,200 | $707,117 | 94 | N/A | Research |
| Bagel Works, Inc. | Accommodation and Food Services | $660,100 | $655,779 | 69 | $12.3M | Research |
| Douglas Company INC | Wholesale Trade | $647,855 | $655,899 | 45 | $13.8M | Research |
| Cloud Staffing Professionals LLC | Professional, Scientific, and Technical Services | $637,500 | $641,168 | 29 | <$5M | Research |
| Chesco, Inc. | Health Care and Social Assistance | $552,500 | $555,573 | 147 | N/A | Research |
| Electronic Imaging Materials, INC | Manufacturing | $523,400 | $483,171 | 40 | $39.7M | Research |
| Whitney Bros. Co. LLC | Manufacturing | $516,490 | $519,943 | 46 | $12.0M | Research |
| Whitney Bros. Co. LLC | Wholesale Trade | $516,400 | $520,758 | 46 | $14.1M | Research |
| General Tours, Inc. | Administrative and Support and Waste Management | $506,900 | $460,891 | 31 | $9.8M | Research |
| Keene Family Ymca | Other Services (except Public Administration) | $463,400 | $466,117 | 160 | $30.6M | Research |
| Keene Publishing Corporation | Information | $460,000 | $490,650 | 55 | $9.2M | Research |
| Keene Family Ymca | Arts, Entertainment, and Recreation | $457,500 | $460,433 | 87 | $12.2M | Research |