| Ben Archer Health Center | Health Care and Social Assistance | $6,189,885 | $6,268,742 | 326 | $102.3M |  Research |
| La Clinica De Familia, INC | Health Care and Social Assistance | $5,428,697 | $5,486,000 | 498 | N/A | Research |
| Tmc Design Corporation | Manufacturing | $3,201,000 | $0 | 174 | $48.6M | Research |
| Tresco INC | Health Care and Social Assistance | $2,949,300 | $2,983,381 | 408 | N/A | Research |
| Borman Motor Compnay LLC | Retail Trade | $1,545,100 | $1,561,796 | 93 | $23.4M | Research |
| Dr. Mark A. Woolf | Health Care and Social Assistance | $1,520,296 | $1,533,416 | 102 | $23.6M | Research |
| Aprendamos Intervention Team PA | Health Care and Social Assistance | $1,518,600 | $1,529,694 | 190 | $30.8M | Research |
| Mountain Shadows Home Care, INC | Health Care and Social Assistance | $1,491,000 | $1,509,886 | 500 | $85.6M | Research |
| Kidskare PC | Health Care and Social Assistance | $1,449,127 | $1,458,933 | 125 | $29.0M | Research |
| Wild West Express, Inc. | Transportation and Warehousing | $1,432,145 | $1,440,738 | 161 | $32.4M | Research |
| Pic Quik | Retail Trade | $1,424,790 | $1,442,560 | 240 | $80.3M | Research |
| Syndetix Inc. | Professional, Scientific, and Technical Services | $1,394,075 | $1,372,772 | 40 | <$5M | Research |
| Las Cruces of Cascadia, LLC | Administrative and Support and Waste Management | $1,391,275 | $903,929 | 82 | $12.9M | Research |
| Multicultural Evaluation & Consultation Associates (meca), L | Health Care and Social Assistance | $1,370,518 | $1,379,466 | 92 | $24.8M | Research |
| Renegade Construction LLC | Construction | $1,165,140 | $1,179,219 | 120 | $45.0M | Research |
| Renegade Construction LLC | Construction | $1,165,100 | $1,170,828 | 120 | $37.2M | Research |
| Electronic Caregiver, Inc. | Health Care and Social Assistance | $990,880 | $998,780 | 114 | $26.4M | Research |
| Mesilla Valley Hospice | Health Care and Social Assistance | $956,330 | $967,886 | 96 | N/A | Research |
| Mesilla Valley Hospice Inc. | Health Care and Social Assistance | $956,330 | $966,186 | 96 | N/A | Research |
| Home Kare INC of Dona Ana | Health Care and Social Assistance | $938,230 | $950,557 | 258 | $44.2M | Research |
| Rodriguez Plastering INC | Construction | $900,900 | $908,798 | 92 | $23.2M | Research |
| Rodriguez Plastering Inc. | Construction | $900,900 | $847,414 | 62 | $15.7M | Research |
| Calibre Post Acute LLC | Health Care and Social Assistance | $863,724 | $874,233 | 120 | $20.4M | Research |
| Smith Engineering Company | Professional, Scientific, and Technical Services | $838,235 | $843,402 | 41 | $5.1M | Research |
| Las Cruces Automotive Group Inc. | Retail Trade | $833,364 | $841,675 | 84 | $21.2M | Research |