| United Cerebral Palsy Association of the North Country, Inc. | Health Care and Social Assistance | $2,489,206 | $2,524,874 | 426 | N/A |  Research |
| Atlantic Testing Laboratories, Limited | Professional, Scientific, and Technical Services | $2,485,445 | $2,512,683 | 233 | $28.7M | Research |
| Frazer Computing, Inc. | Information | $1,729,400 | $1,742,998 | 105 | $17.6M | Research |
| Larch Tree Service, LLC | Administrative and Support and Waste Management | $1,288,733 | $1,304,445 | 76 | $16.5M | Research |
| Larch Tree Service, LLC | Administrative and Support and Waste Management | $1,240,341 | $1,251,725 | 72 | $15.6M | Research |
| United Helpers Canton Nursing Home, Inc. | Health Care and Social Assistance | $1,163,400 | $0 | 207 | N/A | Research |
| College Association, Inc. | Educational Services | $669,330 | $673,254 | 75 | N/A | Research |
| College Association INC | Educational Services | $669,330 | $673,438 | 75 | N/A | Research |
| Laurentian Properties LLC | Accommodation and Food Services | $660,338 | $668,334 | 500 | $156.3M | Research |
| Ray Burns & Sons Trucking INC | Transportation and Warehousing | $566,035 | $574,812 | 37 | $5.6M | Research |
| Thew Associates Pe-Ls Pllc | Professional, Scientific, and Technical Services | $497,220 | $500,598 | 27 | $5.4M | Research |
| Laurentian Properties, LLC | Accommodation and Food Services | $471,670 | $477,253 | 72 | $22.5M | Research |
| Thew Associates Pe-Ls, Pllc | Professional, Scientific, and Technical Services | $420,000 | $422,969 | 33 | $6.7M | Research |
| Jproulx INC | Retail Trade | $411,069 | $413,513 | 100 | $25.0M | Research |
| Northern Lights Home Care Partnership, INC | Health Care and Social Assistance | $384,830 | $387,171 | 45 | N/A | Research |
| Jcp Groceries, Inc. | Retail Trade | $329,985 | $332,977 | 80 | $20.0M | Research |
| Kuno Oil Company, Inc. | Retail Trade | $315,100 | $316,827 | 51 | $17.1M | Research |
| John P, Coakley Sons, Inc. | Retail Trade | $309,700 | $311,457 | 47 | $9.7M | Research |
| Triple a Lumber, Inc. | Retail Trade | $305,900 | $309,202 | 42 | $8.7M | Research |
| St. Lawrence University | Information | $261,407 | $263,942 | 23 | <$5M | Research |
| Northern Lights Health Care Partnership INC | Health Care and Social Assistance | $202,500 | $204,148 | 60 | N/A | Research |
| Greenwood Dairy Farm LLC | Agriculture, Forestry, Fishing and Hunting | $196,848 | $199,458 | 23 | <$5M | Research |
| Healey Medical Practice, Pllc | Health Care and Social Assistance | $188,545 | $191,004 | 19 | $6.0M | Research |
| Canton Animal Clinic Pllc | Professional, Scientific, and Technical Services | $171,055 | $171,875 | 19 | <$5M | Research |
| St Lawrence Dental Studio, Pllc | Health Care and Social Assistance | $161,249 | $163,104 | 10 | <$5M | Research |