| Hospice Buffalo, INC | Health Care and Social Assistance | $4,411,532 | $4,469,305 | 305 | N/A |  Research |
| University Orthopaedic Services, Inc. | Health Care and Social Assistance | $3,830,317 | $3,873,657 | 268 | N/A | Research |
| Maxim Management Services LLC | Professional, Scientific, and Technical Services | $2,204,325 | $2,230,415 | 238 | $33.3M | Research |
| University Orthopaedic Services Inc. | Health Care and Social Assistance | $2,000,000 | $2,013,370 | 291 | N/A | Research |
| Northstar Location Services LLC | Administrative and Support and Waste Management | $1,992,398 | $2,015,379 | 186 | $35.2M | Research |
| 225 Bennett Road Operating Company LLC | Health Care and Social Assistance | $1,953,100 | $2,002,633 | 285 | $48.5M | Research |
| Endeavor Health Services | Health Care and Social Assistance | $1,759,600 | $1,772,472 | 172 | N/A | Research |
| Tectran Mfg INC | Manufacturing | $1,679,932 | $1,690,932 | 163 | $42.7M | Research |
| Tectran Mfg INC | Manufacturing | $1,679,932 | $1,689,505 | 131 | $34.3M | Research |
| Costanzo's Bakery, Inc. | Manufacturing | $1,627,700 | $1,639,384 | 147 | $51.9M | Research |
| C. Basil Ford | Retail Trade | $1,511,647 | $1,525,894 | 116 | $29.2M | Research |
| Amstar of Western New York Inc. | Construction | $1,410,212 | $1,419,176 | 46 | $15.7M | Research |
| Culinary Arts Specialties INC | Manufacturing | $1,070,700 | $1,077,594 | 100 | $35.3M | Research |
| Amar Atwal , MD PC | Health Care and Social Assistance | $955,700 | $963,922 | 113 | $35.5M | Research |
| Superior General Contracting INC | Construction | $908,224 | $915,813 | 90 | $20.8M | Research |
| Amar Atwal M.d. P.c. | Health Care and Social Assistance | $902,435 | $912,844 | 186 | $58.4M | Research |
| Millington Lockwood, Inc. | Wholesale Trade | $898,400 | $904,357 | 74 | $22.7M | Research |
| Gordon Companies Inc. | Wholesale Trade | $895,767 | $902,221 | 174 | $53.3M | Research |
| Garrett Leather Corporation | Wholesale Trade | $872,600 | $880,824 | 79 | $20.3M | Research |
| Big L Distributors Inc. | Retail Trade | $826,485 | $833,187 | 52 | $10.7M | Research |
| Big L Distributors Inc. | Retail Trade | $757,267 | $761,852 | 60 | $12.4M | Research |
| Kohler Awning, Inc. | Construction | $751,800 | $760,513 | 87 | $26.4M | Research |
| Kohler Awning Inc. | Construction | $751,800 | $757,505 | 87 | $26.4M | Research |
| Buffalo Ambulatory Services, Inc. | Health Care and Social Assistance | $743,395 | $750,055 | 97 | $17.3M | Research |
| Buffalo Ambulatory Services Inc. | Health Care and Social Assistance | $741,665 | $749,793 | 187 | $33.3M | Research |