| Horizon Food Equipment, Inc. | Other Services (except Public Administration) | $4,428,000 | $4,484,654 | 292 | $62.8M |  Research |
| Schenectady County Chapter Nysarc INC | Health Care and Social Assistance | $4,272,575 | $750,462 | 500 | $85.1M | Research |
| Schenectady Hardware & Electric Co., Inc. | Construction | $3,679,825 | $3,721,362 | 165 | $54.3M | Research |
| Conifer Park, Inc. | Administrative and Support and Waste Management | $3,660,000 | $3,701,012 | 377 | $71.3M | Research |
| Digesare Mechanical, Inc. | Construction | $2,926,325 | $2,960,140 | 105 | $33.2M | Research |
| Aspen Dental Associates of Hudson Valley, Pllc | Health Care and Social Assistance | $2,622,721 | $2,652,613 | 187 | $43.3M | Research |
| Von Roll Usa, INC | Manufacturing | $2,575,000 | $2,607,170 | 156 | $40.8M | Research |
| Haraden Motorcar Corporation | Retail Trade | $2,310,200 | $2,336,846 | 205 | $51.7M | Research |
| Kingsway Arms Nursing Center, Inc. | Health Care and Social Assistance | $2,284,200 | $2,309,232 | 227 | $38.6M | Research |
| Parkland Ambulance Service INC | Health Care and Social Assistance | $2,236,442 | $2,261,931 | 265 | $61.4M | Research |
| Martin, Harding & Mazzotti, LLP | Professional, Scientific, and Technical Services | $2,169,700 | $2,198,174 | 147 | $35.7M | Research |
| Schenectady Family Health Services Inc. | Health Care and Social Assistance | $2,020,440 | $2,031,843 | 138 | $24.6M | Research |
| Schenectady Hardware & Electric Co. Inc. | Construction | $2,000,000 | $2,019,178 | 103 | $33.9M | Research |
| Aspen Dental Associates of Hudson Valley Pllc | Health Care and Social Assistance | $1,983,446 | $1,994,042 | 220 | $51.0M | Research |
| Cardiology Associates of Schenectady, PC | Health Care and Social Assistance | $1,954,822 | $1,973,246 | 126 | $39.5M | Research |
| Specialty Quality Packaging, LLC | Manufacturing | $1,954,500 | $1,979,186 | 203 | $201.3M | Research |
| Colonie Import Distributors Ltd | Retail Trade | $1,898,240 | $1,923,983 | 164 | $41.3M | Research |
| Colonie Import Distributors Ltd. | Retail Trade | $1,898,240 | $1,916,130 | 160 | $40.3M | Research |
| Martin Harding & Mazzotti LLP | Professional, Scientific, and Technical Services | $1,894,467 | $1,920,107 | 146 | $35.5M | Research |
| American Iron, Inc. | Construction | $1,813,000 | $0 | 80 | $18.5M | Research |
| Metro Ford Sales, Inc. | Retail Trade | $1,565,047 | $1,574,952 | 140 | $35.3M | Research |
| Beekman 1802, Inc. | Manufacturing | $1,495,600 | $1,504,283 | 208 | $206.3M | Research |
| Transfinder Corporation | Professional, Scientific, and Technical Services | $1,417,800 | $1,433,765 | 81 | $16.8M | Research |
| Schenectady Community Action Program, Inc. | Other Services (except Public Administration) | $1,254,958 | $1,264,035 | 137 | N/A | Research |
| Schenectady Pulmonary and Critical Care | Health Care and Social Assistance | $1,221,821 | $1,234,943 | 44 | $13.8M | Research |