| Developmental Disabilities Institute INC | Health Care and Social Assistance | $10,000,000 | $10,074,167 | 500 | $85.1M |  Research |
| Community Care Companions INC - Duplicate | Health Care and Social Assistance | $6,857,060 | $6,945,059 | 500 | $85.6M | Research |
| Lane-Valente Industries INC | Construction | $4,636,385 | $4,697,220 | 291 | $331.5M | Research |
| Optima Care Smithtown LLC | Health Care and Social Assistance | $4,153,750 | $4,208,033 | 369 | $62.8M | Research |
| Aron Security INC | Administrative and Support and Waste Management | $4,052,840 | $4,107,666 | 500 | $73.2M | Research |
| Professional Practice Administrators INC | Health Care and Social Assistance | $3,750,000 | $39,263 | 4 | <$5M | Research |
| Lane-Valente Industries INC | Administrative and Support and Waste Management | $2,000,000 | $2,022,104 | 280 | $53.0M | Research |
| Kld Associates, INC | Professional, Scientific, and Technical Services | $1,735,989 | $1,088,158 | 140 | $29.0M | Research |
| Sc Auto Corp | Retail Trade | $1,706,675 | $1,724,263 | 93 | $23.4M | Research |
| S.c. Auto Corp | Retail Trade | $1,706,675 | $1,728,814 | 121 | $30.5M | Research |
| Guide Dog Foundation for the Blind INC | Other Services (except Public Administration) | $1,457,000 | $1,475,172 | 140 | N/A | Research |
| Equity Settlement Services INC | Professional, Scientific, and Technical Services | $1,447,476 | $1,458,620 | 127 | $34.7M | Research |
| King O'rourke Cadillac Inc. | Retail Trade | $1,231,997 | $1,249,245 | 71 | $17.9M | Research |
| Suburban Pest Management LLC | Administrative and Support and Waste Management | $1,228,500 | $1,238,867 | 117 | $25.3M | Research |
| Law Offices of Mark Debeneditis | Professional, Scientific, and Technical Services | $1,157,765 | $11,759 | 1 | <$5M | Research |
| Smithtown Steakhouse LLC | Accommodation and Food Services | $1,060,654 | $1,070,995 | 93 | $16.5M | Research |
| Suffolk Heart Group | Health Care and Social Assistance | $959,200 | $0 | 75 | $23.5M | Research |
| Scotto Smithtown Restaurant Corp | Accommodation and Food Services | $932,477 | $940,481 | 45 | $8.4M | Research |
| M&l Mechanical of New York Inc. | Construction | $850,159 | $797,136 | 20 | $6.3M | Research |
| Practice Management of America, Inc. | Administrative and Support and Waste Management | $825,200 | $832,627 | 80 | $15.1M | Research |
| Kenneth O. Wille & Assoc., Inc. | Professional, Scientific, and Technical Services | $807,354 | $612,757 | 30 | $6.0M | Research |
| Polish of Smithtown LLC | Retail Trade | $806,000 | $816,445 | 98 | $15.3M | Research |
| E.l.m. General Construction Corp | Construction | $767,683 | $774,118 | 50 | $11.6M | Research |
| Elm General Construction | Administrative and Support and Waste Management | $767,600 | $775,980 | 50 | $10.8M | Research |
| Smithtown Steakhouse LLC | Arts, Entertainment, and Recreation | $757,610 | $765,965 | 93 | $15.3M | Research |