| Wiggins and Giles, Dds, PA | Health Care and Social Assistance | $302,000 | $304,772 | 26 | $6.0M |  Research |
| Wake Futbol Club INC | Other Services (except Public Administration) | $300,800 | $16,370 | 80 | N/A | Research |
| Holly Springs Surgery Center, LLC | Health Care and Social Assistance | $293,600 | $296,903 | 22 | <$5M | Research |
| Svg Concrete Services Inc. | Construction | $285,300 | $287,606 | 18 | <$5M | Research |
| P.b.m, Inc. | Administrative and Support and Waste Management | $279,305 | $280,751 | 72 | $15.6M | Research |
| Passion for Wow, Inc. | Other Services (except Public Administration) | $275,475 | $279,316 | 30 | $5.7M | Research |
| Rodney's Custom Cut Sign Co., Inc. | Other Services (except Public Administration) | $268,600 | $270,749 | 27 | $5.2M | Research |
| Harvest Holly Springs LLC | Accommodation and Food Services | $266,816 | $269,848 | 49 | $8.7M | Research |
| My Way Tavern, LLC | Accommodation and Food Services | $265,100 | $266,778 | 50 | $8.9M | Research |
| Svg Concrete Pumping Inc. | Construction | $262,385 | $265,257 | 24 | $5.6M | Research |
| T & B Concepts of Holly Springs, LLC | Accommodation and Food Services | $259,947 | $261,948 | 32 | $5.7M | Research |
| Directus Holdings, LLC | Manufacturing | $259,100 | $253,906 | 18 | <$5M | Research |
| Southern Mechanical Insulation of Nc LLC | Construction | $256,900 | $194,259 | 23 | $7.3M | Research |
| Scratch Kitchen and Taproom, LLC | Accommodation and Food Services | $255,000 | $256,501 | 72 | $12.8M | Research |
| The Mason Jar Tavern INC | Accommodation and Food Services | $254,347 | $256,318 | 65 | $11.5M | Research |
| Mkm II Educational Services Company | Health Care and Social Assistance | $252,500 | $254,492 | 45 | $7.3M | Research |
| Falcon Eh&s INC | Construction | $250,968 | $25,328 | 1 | <$5M | Research |
| General Concrete Construction INC | Construction | $240,138 | $243,566 | 16 | <$5M | Research |
| Mi Cancun of Holly Springs INC | Accommodation and Food Services | $238,900 | $241,136 | 31 | $5.5M | Research |
| Ideal Services Company | Construction | $228,300 | $230,019 | 20 | $6.3M | Research |
| Sonshine Gymnastics INC | Educational Services | $228,043 | $229,865 | 59 | $7.7M | Research |
| Sonshine Gymnastics INC | Educational Services | $228,000 | $229,951 | 106 | $13.8M | Research |
| Ideal Services Company | Construction | $223,608 | $224,614 | 18 | $5.7M | Research |
| Arr Entertainment, INC | Accommodation and Food Services | $220,358 | $224,584 | 22 | <$5M | Research |
| General Concrete Construction, Inc. | Construction | $217,249 | $220,582 | 19 | <$5M | Research |