| James R Vannoy & Sons Construction Company INC | Construction | $5,346,090 | $5,406,288 | 330 | $376.0M |  Research |
| Ashe Memorial Hospital Inc. | Health Care and Social Assistance | $2,600,000 | $2,635,172 | 236 | $46.8M | Research |
| Margate Health & Rehab Center LLC | Health Care and Social Assistance | $747,700 | $753,869 | 107 | $18.2M | Research |
| Mcfarland & Company, Inc., Publishers | Information | $467,700 | $471,044 | 48 | $8.1M | Research |
| Ossiriand, Inc. | Unknown | $249,815 | $252,060 | 29 | N/A | Research |
| Padco Excavating Inc. | Construction | $231,100 | $233,576 | 30 | $11.2M | Research |
| Jl Golf Management | Arts, Entertainment, and Recreation | $219,218 | $221,288 | 25 | <$5M | Research |
| Appalachian Utilities INC | Construction | $207,227 | $209,443 | 37 | $11.5M | Research |
| High Country Family Medicine, P.a. | Health Care and Social Assistance | $187,370 | $0 | 14 | <$5M | Research |
| Aloia Enterprises INC | Retail Trade | $168,200 | $169,126 | 44 | $11.0M | Research |
| Charles Jones W. M.d. P.a. | Health Care and Social Assistance | $134,589 | $135,778 | 7 | <$5M | Research |
| Charles W Jones MD PA | Health Care and Social Assistance | $134,500 | $135,774 | 8 | <$5M | Research |
| Unique Home Care, Inc. | Health Care and Social Assistance | $134,339 | $136,073 | 40 | $6.9M | Research |
| Carolina Grading and Utilities INC | Construction | $132,803 | $134,278 | 21 | $6.5M | Research |
| Sheets Brothers Inc. | Construction | $98,500 | $99,121 | 10 | <$5M | Research |
| Sheets Brothers INC | Construction | $90,800 | $91,370 | 12 | <$5M | Research |
| Laid Right Site Development, Inc. | Public Administration | $89,686 | $90,593 | 12 | N/A | Research |
| Joel W. Yates Jr. D.d.s.p.l.l.c | Health Care and Social Assistance | $88,200 | $88,981 | 12 | <$5M | Research |
| Joel W. Yates Jr. D.d.s. P.l.l.c. | Health Care and Social Assistance | $85,200 | $86,253 | 10 | <$5M | Research |
| Schuster Physical Therapy Inc. | Health Care and Social Assistance | $84,733 | $85,231 | 8 | <$5M | Research |
| The Animal Hospital of Ashe PA | Professional, Scientific, and Technical Services | $82,000 | $75,850 | 8 | <$5M | Research |
| Ashe Developmental Day School INC | Health Care and Social Assistance | $79,388 | $79,823 | 20 | <$5M | Research |
| Appalachian Utilities Technical Support LP | Construction | $75,205 | $75,957 | 6 | <$5M | Research |
| Susan Absher | Other Services (except Public Administration) | $73,377 | $73,642 | 7 | <$5M | Research |
| G.k.b., Inc. | Administrative and Support and Waste Management | $61,200 | $61,754 | 7 | <$5M | Research |