| Healthkeeperz INC | Health Care and Social Assistance | $2,056,165 | $2,080,107 | 161 | $27.6M |  Research |
| Robeson Health Care Corporation | Health Care and Social Assistance | $1,846,700 | $1,868,553 | 234 | $54.2M | Research |
| Lumbee Tribe Enterprises, LLC | Professional, Scientific, and Technical Services | $1,428,950 | $1,444,140 | 122 | $12.6M | Research |
| Metcon, Inc. | Construction | $1,162,133 | $1,169,488 | 81 | $92.3M | Research |
| Pembroke Hardware Company INC | Retail Trade | $454,272 | $458,329 | 61 | $12.6M | Research |
| East Coast Electrical Construction Inc. | Construction | $349,404 | $351,529 | 25 | $8.2M | Research |
| Air Production & Service, INC | Transportation and Warehousing | $320,300 | $322,391 | 26 | <$5M | Research |
| Trinity Frozen Foods, LLC | Manufacturing | $319,300 | $327,620 | 38 | $13.4M | Research |
| Trinity Frozen Foods LLC | Manufacturing | $319,279 | $325,079 | 46 | $16.2M | Research |
| Dignity Home Care, LLC | Health Care and Social Assistance | $243,287 | $244,773 | 62 | $10.6M | Research |
| American Contractors LLC | Administrative and Support and Waste Management | $229,474 | $136,220 | 40 | $8.7M | Research |
| Collins & Sampson D.d.s., P.a. | Health Care and Social Assistance | $219,300 | $222,163 | 27 | $6.3M | Research |
| Collins and Sampson DDS PA | Health Care and Social Assistance | $193,649 | $195,327 | 9 | <$5M | Research |
| Speech N Progress, Inc. | Health Care and Social Assistance | $140,142 | $141,382 | 15 | <$5M | Research |
| Heavenly Touch, LLC | Health Care and Social Assistance | $136,892 | $137,818 | 56 | $9.1M | Research |
| Chaparral Youth Services Ii, LLC | Health Care and Social Assistance | $132,924 | $133,816 | 60 | $9.7M | Research |
| Speech N Progress Inc. | Health Care and Social Assistance | $129,878 | $130,447 | 15 | <$5M | Research |
| Rowland Old Main, INC | Retail Trade | $124,800 | $125,968 | 15 | <$5M | Research |
| San Jose Mexican Restaurant of Pembroke, Nc, Inc. | Accommodation and Food Services | $109,899 | $110,781 | 21 | <$5M | Research |
| Pembroke Waste Collections Inc. | Administrative and Support and Waste Management | $103,642 | $104,250 | 15 | <$5M | Research |
| The Dekk Corporation | Construction | $100,000 | $101,370 | 11 | $12.5M | Research |
| Speech Fundamentals Pllc | Health Care and Social Assistance | $100,000 | $101,114 | 11 | <$5M | Research |
| West Primary Care, Inc. | Health Care and Social Assistance | $99,200 | $99,999 | 9 | <$5M | Research |
| Southern Christian Transportation, INC | Transportation and Warehousing | $98,927 | $99,632 | 20 | <$5M | Research |
| Eco Building Corporation | Professional, Scientific, and Technical Services | $98,900 | $99,752 | 6 | <$5M | Research |