| Troxler Electronic Laboratories, INC | Manufacturing | $1,448,600 | $1,406,085 | 107 | $28.0M |  Research |
| Zaloni Inc. | Professional, Scientific, and Technical Services | $966,100 | $975,788 | 42 | $8.7M | Research |
| Instrotek INC | Manufacturing | $584,000 | $589,078 | 55 | $13.4M | Research |
| Uai Technology INC | Professional, Scientific, and Technical Services | $406,956 | $411,159 | 23 | <$5M | Research |
| Uai Technology INC | Information | $406,955 | $409,742 | 23 | <$5M | Research |
| Integralabs, Inc. | Health Care and Social Assistance | $404,300 | $409,661 | 42 | $9.7M | Research |
| Sigma Xi the Scientific Research Honor Society Inc. | Other Services (except Public Administration) | $387,943 | $390,195 | 28 | $5.3M | Research |
| Rxdatascience INC | Information | $380,437 | $383,345 | 22 | <$5M | Research |
| Cutting Edge Information LLC | Information | $178,988 | $180,793 | 9 | <$5M | Research |
| Panacea Biomatx INC | Manufacturing | $161,924 | $162,608 | 9 | <$5M | Research |
| Council for Entrepreneurial Development (ced) | Educational Services | $149,200 | $150,157 | 5 | N/A | Research |
| National Institute of Statistical Sciences | Professional, Scientific, and Technical Services | $143,000 | $143,743 | 7 | <$5M | Research |
| Novus Energy Technologies Inc. | Manufacturing | $142,500 | $0 | 10 | <$5M | Research |
| Galaxy Diagnostics Inc. | Health Care and Social Assistance | $118,808 | $119,468 | 10 | <$5M | Research |
| North Carolina Biotechnology Center | Agriculture, Forestry, Fishing and Hunting | $114,500 | $115,559 | 69 | N/A | Research |
| North Carolina Biotechnology Center | Agriculture, Forestry, Fishing and Hunting | $100,000 | $0 | 69 | N/A | Research |
| First Flight Venture Center, Inc. | Public Administration | $89,317 | $90,198 | 6 | N/A | Research |
| Lindy Biosciences, Inc. | Finance and Insurance | $87,194 | $94,508 | 6 | <$5M | Research |
| Breezi.io, Inc. | Manufacturing | $82,615 | $83,833 | 9 | <$5M | Research |
| Avolynt INC | Professional, Scientific, and Technical Services | $74,435 | $83,522 | 4 | <$5M | Research |
| Continuous Precision Medicine Inc. | Health Care and Social Assistance | $73,283 | $73,935 | 5 | <$5M | Research |
| Nc Healthcare Information and Communicat | Unknown | $63,701 | $64,273 | 3 | N/A | Research |
| Imaps-International Microelectronics and Packaging Society | Other Services (except Public Administration) | $61,100 | $61,248 | 4 | N/A | Research |
| Bioaesthetics Corporation | Professional, Scientific, and Technical Services | $54,532 | $54,903 | 4 | <$5M | Research |
| Evecxia, Inc. | Professional, Scientific, and Technical Services | $51,260 | $51,627 | 2 | <$5M | Research |