| Rvh Transport, INC | Transportation and Warehousing | $125,900 | $126,862 | 25 | <$5M | AI Deep Dive |
| Spruce Pine Chevrolet | Retail Trade | $118,800 | $119,422 | 18 | <$5M | AI Deep Dive |
| Mitchell County Productions | Information | $117,707 | $117,955 | 6 | <$5M | AI Deep Dive |
| Appalachian Eye Associates, Od, PA | Health Care and Social Assistance | $108,500 | $109,080 | 13 | <$5M | AI Deep Dive |
| Embark LLC | Administrative and Support and Waste Management | $96,250 | $96,630 | 4 | <$5M | AI Deep Dive |
| Cardinal Insurance, LLC | Finance and Insurance | $94,800 | $95,244 | 10 | $5.1M | AI Deep Dive |
| Young Miller & Associates PA | Professional, Scientific, and Technical Services | $94,700 | $95,281 | 16 | $5.1M | AI Deep Dive |
| Spruce Pine Montessori School, Inc. | Health Care and Social Assistance | $90,000 | $90,666 | 19 | N/A | AI Deep Dive |
| Appalachian Eye Associatesodpa | Health Care and Social Assistance | $86,900 | $87,214 | 13 | <$5M | AI Deep Dive |
| Alta Ridge Foot Specialists Pllc | Health Care and Social Assistance | $83,700 | $84,432 | 10 | <$5M | AI Deep Dive |
| Boones Concrete Supply LLC | Transportation and Warehousing | $81,250 | $82,278 | 17 | <$5M | AI Deep Dive |
| Stamey Enterprises | Retail Trade | $77,500 | $77,963 | 18 | $6.0M | AI Deep Dive |
| Stewart's Mountain View Animal Hospital | Professional, Scientific, and Technical Services | $74,088 | $74,908 | 18 | <$5M | AI Deep Dive |
| David Whitson | Construction | $73,900 | $74,337 | 15 | <$5M | AI Deep Dive |
| Dorothy Renfro | Health Care and Social Assistance | $70,157 | $70,722 | 1 | <$5M | AI Deep Dive |
| Rvh, Inc. | Transportation and Warehousing | $64,600 | $65,094 | 14 | <$5M | AI Deep Dive |
| Gouge Transportation & Equipment Co., Inc. | Transportation and Warehousing | $64,500 | $65,166 | 8 | <$5M | AI Deep Dive |
| Hospital Drive Pharmacy INC | Retail Trade | $63,200 | $63,890 | 13 | <$5M | AI Deep Dive |
| Luke Enterprises, Inc. | Retail Trade | $62,500 | $62,848 | 10 | <$5M | AI Deep Dive |
| Spruce Pine Batch INC | Manufacturing | $61,100 | $61,452 | 11 | <$5M | AI Deep Dive |
| Spruce Pine Tire Service Inc. | Retail Trade | $52,200 | $52,616 | 8 | <$5M | AI Deep Dive |
| Dt Niven Enterprises INC | Accommodation and Food Services | $50,900 | $51,201 | 14 | <$5M | AI Deep Dive |
| Julius Aldridge, D.d.s., P.a. | Health Care and Social Assistance | $48,100 | $48,397 | 6 | <$5M | AI Deep Dive |
| Julius Aldridge DDS PA | Health Care and Social Assistance | $48,100 | $48,323 | 6 | <$5M | AI Deep Dive |
| The Center for Rural Health Innovation | Other Services (except Public Administration) | $47,200 | $47,371 | 14 | <$5M | AI Deep Dive |