| Jackson Paper Manufacturing Company | Manufacturing | $3,042,400 | $3,096,656 | 215 | $213.2M |  Research |
| Meridian Behavioral Health Services INC | Health Care and Social Assistance | $1,786,700 | $1,809,977 | 180 | N/A | Research |
| Skyland Care Center | Health Care and Social Assistance | $900,616 | $909,055 | 165 | $28.1M | Research |
| B. H. Graning Landscapes Inc. | Professional, Scientific, and Technical Services | $552,000 | $560,363 | 79 | $15.9M | Research |
| B H Graning Landscapes INC | Administrative and Support and Waste Management | $537,000 | $542,444 | 73 | $15.8M | Research |
| Sundog Club INC | Administrative and Support and Waste Management | $501,948 | $504,795 | 77 | $14.6M | Research |
| Andy Shaw Ford INC | Retail Trade | $478,196 | $481,689 | 43 | $10.8M | Research |
| Mountain Ear Nose and Throat Associates | Health Care and Social Assistance | $474,500 | $480,246 | 34 | $10.7M | Research |
| Sundog Club INC | Real Estate and Rental and Leasing | $447,700 | $450,055 | 33 | <$5M | Research |
| Strawberry Insurance Agency | Finance and Insurance | $414,000 | $419,297 | 35 | $18.0M | Research |
| Southern Resort Group LLC | Real Estate and Rental and Leasing | $387,979 | $389,754 | 235 | $35.3M | Research |
| Mountain Ear Nose & Throat Associates P.a. | Health Care and Social Assistance | $382,500 | $386,294 | 35 | $11.0M | Research |
| Pathways for the Future Inc. | Health Care and Social Assistance | $366,400 | $368,618 | 80 | N/A | Research |
| The Club at Balsam Mountain, Inc. | Arts, Entertainment, and Recreation | $318,877 | $322,337 | 40 | $5.6M | Research |
| Western Carolina Digestive Consultants P.a. | Health Care and Social Assistance | $311,500 | $317,346 | 23 | $7.2M | Research |
| Trwh INC | Retail Trade | $275,510 | $277,827 | 40 | $10.8M | Research |
| Southern Resort Group LLC | Real Estate and Rental and Leasing | $271,200 | $274,120 | 40 | $6.0M | Research |
| Western Builders of Sylva INC | Construction | $260,984 | $263,318 | 28 | $31.9M | Research |
| Webster Enterprises-Jacksn Cty | Health Care and Social Assistance | $231,100 | $232,746 | 44 | $7.1M | Research |
| Skyland House, LLC | Health Care and Social Assistance | $227,860 | $229,427 | 43 | $7.3M | Research |
| Allison Outdoor Advertising, LP | Professional, Scientific, and Technical Services | $216,300 | $218,001 | 19 | <$5M | Research |
| Current Dermatology Pllc | Health Care and Social Assistance | $194,100 | $194,701 | 18 | $5.6M | Research |
| Current Dermatology Pllc | Health Care and Social Assistance | $194,100 | $195,483 | 18 | $5.6M | Research |
| Aaa Greene Bros Well Drlg of Sylva INC | Mining, Quarrying, and Oil and Gas Extraction | $187,800 | $190,213 | 18 | <$5M | Research |
| Smart Choice Services Plumbing, Heating, and Air, Inc. | Construction | $176,700 | $177,659 | 24 | $7.6M | Research |