| Good Samaritan Hospital Association | Health Care and Social Assistance | $2,857,200 | $2,890,077 | 338 | N/A |  Research |
| Envision | Agriculture, Forestry, Fishing and Hunting | $1,311,625 | $1,254,792 | 101 | $5.1M | Research |
| Center Mutual Insurance Company | Finance and Insurance | $458,400 | $461,036 | 26 | $13.4M | Research |
| Rugby Farmers Elevator | Wholesale Trade | $333,050 | $334,956 | 18 | <$5M | Research |
| Mj Mcguire Company | Retail Trade | $284,500 | $286,744 | 22 | $5.5M | Research |
| Rugby Homes and Rv Center | Wholesale Trade | $275,800 | $277,493 | 15 | <$5M | Research |
| Rugby Farmers Elevator | Wholesale Trade | $256,240 | $257,329 | 19 | <$5M | Research |
| Deplazes Redi-Mix and Construction LLC | Construction | $229,300 | $230,801 | 16 | <$5M | Research |
| Rugby Homes & Rv Center Inc. | Wholesale Trade | $223,400 | $224,697 | 16 | <$5M | Research |
| Central Transport, LLC | Transportation and Warehousing | $197,200 | $199,528 | 8 | <$5M | Research |
| St. Michel Furniture, Inc. | Retail Trade | $188,900 | $190,684 | 18 | <$5M | Research |
| Central Carriers, Inc. | Transportation and Warehousing | $165,900 | $166,891 | 12 | <$5M | Research |
| Johnsons Plumbing INC | Construction | $164,100 | $165,303 | 12 | <$5M | Research |
| Central Transport LLC | Transportation and Warehousing | $160,461 | $160,974 | 8 | <$5M | Research |
| Rugby Dental Office, PC | Health Care and Social Assistance | $157,800 | $158,769 | 9 | <$5M | Research |
| Hartley's School Buses Inc. | Transportation and Warehousing | $145,500 | $146,118 | 25 | $9.6M | Research |
| Rugby Lumber, Inc. | Retail Trade | $137,100 | $137,885 | 9 | <$5M | Research |
| Little Flower Church & School | Other Services (except Public Administration) | $132,900 | $133,636 | 9 | N/A | Research |
| Hartley's School Buses, Inc. | Transportation and Warehousing | $124,800 | $125,611 | 14 | $5.4M | Research |
| Rugby Veterinary Service, PC | Professional, Scientific, and Technical Services | $122,200 | $122,882 | 11 | <$5M | Research |
| B & J Excavating INC | Construction | $117,917 | $118,741 | 9 | <$5M | Research |
| Rugby Livestock Auction LLC | Wholesale Trade | $113,700 | $114,313 | 46 | $11.8M | Research |
| Rugby Dental Office PC | Health Care and Social Assistance | $111,800 | $112,238 | 9 | <$5M | Research |
| D & S Motors Inc. | Retail Trade | $102,500 | $103,171 | 10 | <$5M | Research |
| Rugby Livestock Auction LLC | Wholesale Trade | $97,640 | $97,938 | 45 | $11.6M | Research |