| One Community Health | Health Care and Social Assistance | $3,055,393 | $3,090,551 | 175 | N/A |  Research |
| Duckwall-Pooley Fruit Co. | Agriculture, Forestry, Fishing and Hunting | $2,561,532 | $2,603,288 | 202 | $10.1M | Research |
| Turtle Island Foods, Spc | Manufacturing | $2,207,657 | $2,236,864 | 204 | $72.0M | Research |
| Columbia Room INC | Accommodation and Food Services | $1,594,512 | $1,606,132 | 149 | $46.6M | Research |
| Diamond Fruit Growers INC | Wholesale Trade | $1,503,800 | $1,519,909 | 253 | $65.1M | Research |
| Hood River Distillers, INC | Manufacturing | $1,358,087 | $1,375,648 | 69 | $24.4M | Research |
| B C Marketing Concepts Inc. | Manufacturing | $1,284,600 | $1,302,584 | 105 | $37.1M | Research |
| Hood River Juice Company | Manufacturing | $1,255,992 | $1,144,314 | 105 | $37.1M | Research |
| Hood River Juice Company | Wholesale Trade | $1,244,459 | $1,255,165 | 121 | $31.1M | Research |
| Columbia Room INC | Accommodation and Food Services | $1,138,940 | $1,147,053 | 193 | $60.3M | Research |
| Double Mountain LLC | Accommodation and Food Services | $1,085,000 | $1,099,952 | 76 | $14.2M | Research |
| Inspiring Healthcare Resources LLC | Health Care and Social Assistance | $990,565 | $997,648 | 115 | $19.7M | Research |
| Dakine Equipment LLC | Wholesale Trade | $925,000 | $933,743 | 59 | $18.1M | Research |
| Double Mountain LLC | Manufacturing | $841,224 | $852,656 | 57 | $20.1M | Research |
| Pfriem Brewing Co LLC | Manufacturing | $804,287 | $809,311 | 47 | $16.6M | Research |
| Pfriem Brewing Co LLC | Wholesale Trade | $763,538 | $769,123 | 61 | $15.7M | Research |
| Inter-Fluve, Inc. | Professional, Scientific, and Technical Services | $710,100 | $719,030 | 44 | $5.4M | Research |
| Webster Orchards INC | Agriculture, Forestry, Fishing and Hunting | $665,758 | $671,375 | 50 | $5.1M | Research |
| Webster Orchards, Inc. | Agriculture, Forestry, Fishing and Hunting | $665,757 | $669,752 | 65 | $6.6M | Research |
| The Next Door, INC | Other Services (except Public Administration) | $645,300 | $649,720 | 68 | N/A | Research |
| Farmers Conservation Alliance | Other Services (except Public Administration) | $552,627 | $556,049 | 31 | N/A | Research |
| Advanced Navigation & Position Corporation | Manufacturing | $547,257 | $550,525 | 33 | $8.6M | Research |
| Dominguez Family Enterprises, Inc. | Manufacturing | $546,685 | $552,556 | 67 | $23.6M | Research |
| A 1 Hotels LLC | Accommodation and Food Services | $545,622 | $549,553 | 120 | $37.5M | Research |
| Coburn Electric INC | Construction | $541,100 | $546,926 | 21 | $6.9M | Research |