| La Clinca Del Valle Family Health Center, Inc. | Health Care and Social Assistance | $4,842,147 | $4,897,069 | 413 | N/A |  Research |
| Action Financial Services, LLC | Finance and Insurance | $2,550,600 | $2,582,046 | 270 | $138.7M | Research |
| Rogue Valley Physicians, P.c. | Health Care and Social Assistance | $2,458,400 | $2,485,678 | 110 | $34.5M | Research |
| Southern Oregon Goodwill Industries | Retail Trade | $2,440,188 | $2,468,269 | 366 | $69.4M | Research |
| Prs Management INC | Professional, Scientific, and Technical Services | $2,350,497 | $2,011,116 | 131 | $13.6M | Research |
| Southern Oregon Orthopedics, INC | Health Care and Social Assistance | $2,283,000 | $2,312,398 | 131 | $41.1M | Research |
| Rogue Community Health | Health Care and Social Assistance | $2,267,600 | $2,294,501 | 205 | N/A | Research |
| Naumes, Inc. | Agriculture, Forestry, Fishing and Hunting | $2,182,700 | $2,209,519 | 270 | $27.6M | Research |
| Mercy Flights, Incorporated. | Health Care and Social Assistance | $2,164,815 | $2,188,387 | 150 | N/A | Research |
| Naumes, Inc. | Agriculture, Forestry, Fishing and Hunting | $2,000,000 | $2,017,111 | 241 | $24.6M | Research |
| Southern Oregon Goodwill Ind | Retail Trade | $2,000,000 | $2,016,932 | 262 | $49.7M | Research |
| The Medford Radiological Group PC | Health Care and Social Assistance | $1,767,520 | $1,778,125 | 118 | $37.0M | Research |
| Medical Eye Center Inc. | Health Care and Social Assistance | $1,576,111 | $1,589,065 | 166 | $52.1M | Research |
| Medical Eye Center, INC | Health Care and Social Assistance | $1,503,300 | $1,514,992 | 120 | $28.1M | Research |
| Waterford Operations, LLC | Health Care and Social Assistance | $1,441,900 | $1,460,230 | 199 | $33.9M | Research |
| Surgery Center of Southern Oregon, LLC | Health Care and Social Assistance | $1,398,480 | $1,407,024 | 104 | $18.5M | Research |
| Addictions Recovery Center, INC | Health Care and Social Assistance | $1,320,900 | $1,339,537 | 125 | N/A | Research |
| Hematology Oncology Associates, PC | Health Care and Social Assistance | $1,312,900 | $1,233,124 | 135 | $42.4M | Research |
| St. Mary's School of Meford, Inc. | Educational Services | $1,273,351 | $1,282,159 | 97 | N/A | Research |
| Living Opportunities | Other Services (except Public Administration) | $1,260,832 | $1,269,639 | 140 | N/A | Research |
| Ontrack, Inc. | Health Care and Social Assistance | $1,206,100 | $1,214,978 | 103 | N/A | Research |
| J.b Steel, Inc. | Construction | $1,137,500 | $1,145,572 | 67 | $22.8M | Research |
| Homecare Delivery Services, LLC | Health Care and Social Assistance | $1,133,420 | $1,142,518 | 274 | $46.9M | Research |
| Airport Chevrolet Inc. | Retail Trade | $1,115,977 | $1,122,642 | 100 | $25.2M | Research |
| Southern Oregon Cardiology, LLC | Health Care and Social Assistance | $1,104,500 | $1,111,894 | 107 | $33.6M | Research |