| Db Roseburg INC | Manufacturing | $492,600 | $498,376 | 135 | $47.6M |  Research |
| P.k. Guido, Inc. | Manufacturing | $491,800 | $496,543 | 45 | $44.6M | Research |
| Restaurant Development Company of Roseburg LLC | Accommodation and Food Services | $476,184 | $480,033 | 64 | $11.4M | Research |
| Pacific Air Comfort INC | Construction | $464,700 | $468,354 | 50 | $15.8M | Research |
| Umpqua Property Services LLC | Real Estate and Rental and Leasing | $460,100 | $464,827 | 42 | $6.3M | Research |
| Golden Nw, LLC | Accommodation and Food Services | $452,000 | $457,236 | 111 | $19.7M | Research |
| Lotus Media Group LLC | Information | $440,310 | $443,181 | 51 | $8.6M | Research |
| Lotus Media Group LLC | Information | $427,300 | $431,468 | 54 | $9.1M | Research |
| Dash Enterprises of Roseburg, Inc. | Retail Trade | $421,932 | $427,335 | 34 | $8.6M | Research |
| Sdi NW LLC | Accommodation and Food Services | $413,600 | $416,603 | 96 | $17.0M | Research |
| Whit-Log, Inc. | Manufacturing | $392,200 | $394,510 | 31 | $8.1M | Research |
| Advantage Home Care Douglas County INC | Health Care and Social Assistance | $387,600 | $391,455 | 50 | $8.6M | Research |
| Wicks Emmett LLP | Professional, Scientific, and Technical Services | $383,800 | $385,631 | 31 | $9.9M | Research |
| Wicks Emmett LLP | Professional, Scientific, and Technical Services | $371,886 | $374,382 | 25 | $8.0M | Research |
| Community Cancer Foundation | Health Care and Social Assistance | $371,000 | $373,474 | 21 | N/A | Research |
| Young Men's Christian Association of Dougals County | Other Services (except Public Administration) | $356,055 | $359,216 | 54 | N/A | Research |
| I.e. Engineering, Inc. | Construction | $355,900 | $359,917 | 22 | $6.8M | Research |
| Young Men's Christian Association of Dougals County | Health Care and Social Assistance | $337,500 | $344,416 | 160 | N/A | Research |
| T3 Construction LLC | Construction | $332,000 | $334,074 | 18 | $5.6M | Research |
| Triptych Construction LLC | Construction | $329,782 | $332,149 | 21 | $7.2M | Research |
| Restaurant Development Company of Roseburg LLC | Accommodation and Food Services | $327,700 | $331,390 | 64 | $11.4M | Research |
| Umpqua Orthopedics | Health Care and Social Assistance | $325,000 | $326,950 | 26 | $8.2M | Research |
| Roseburg Disposal Co | Administrative and Support and Waste Management | $309,100 | $312,157 | 21 | <$5M | Research |
| Bruce Standley Construction | Agriculture, Forestry, Fishing and Hunting | $308,603 | $313,093 | 24 | <$5M | Research |
| Oregon Linen, Inc. | Other Services (except Public Administration) | $307,200 | $310,163 | 32 | $6.1M | Research |