| All My Children Daycare & Nursery School | Health Care and Social Assistance | $2,655,057 | $0 | 324 | N/A |  Research |
| The Wyoming Seminary of the Susquehanna Annual Conference of | Educational Services | $2,535,800 | $2,564,891 | 237 | N/A | Research |
| Sordoni Construction Services, Inc. | Construction | $1,563,529 | $1,574,881 | 88 | $100.3M | Research |
| Institute for Human Resources and Services | Health Care and Social Assistance | $1,468,212 | $1,476,619 | 98 | $15.9M | Research |
| Arrow Auto Glass Operating Company, LLC | Other Services (except Public Administration) | $1,429,000 | $1,436,979 | 98 | $19.2M | Research |
| Rutkoski Fencing, Inc. | Construction | $1,076,401 | $1,088,182 | 32 | $10.9M | Research |
| Trans Med Ambulance INC | Health Care and Social Assistance | $1,048,300 | $1,062,103 | 99 | $22.9M | Research |
| Nicholas Trucking Co INC | Transportation and Warehousing | $965,300 | $970,690 | 100 | $26.7M | Research |
| Qsc Enterprises INC | Accommodation and Food Services | $933,000 | $940,592 | 286 | $50.8M | Research |
| Apollo Group INC | Construction | $900,000 | $908,236 | 61 | $20.1M | Research |
| Apollo Group Inc. | Construction | $900,000 | $908,211 | 57 | $18.8M | Research |
| Hourigan Kluger & Quinn PC | Administrative and Support and Waste Management | $899,700 | $905,098 | 45 | $8.5M | Research |
| Compass Home Health & Rehab LLC | Health Care and Social Assistance | $791,200 | $797,046 | 74 | $12.7M | Research |
| The Penn Warranty Corporation | Finance and Insurance | $785,100 | $790,879 | 52 | $26.7M | Research |
| Compass Home Health & Rehab LLC | Health Care and Social Assistance | $784,435 | $789,970 | 62 | $10.6M | Research |
| Nepa Home Care, Inc. | Health Care and Social Assistance | $750,700 | $756,789 | 154 | $24.9M | Research |
| Custom Staffing Solutions LLC | Administrative and Support and Waste Management | $741,865 | $748,418 | 120 | $18.9M | Research |
| Rome Enterprises, Inc. | Retail Trade | $719,200 | $727,436 | 42 | $8.7M | Research |
| A. Pickett Construction, Inc. / Pickett Facilities Maintenan | Construction | $719,113 | $723,053 | 52 | $59.2M | Research |
| A. Pickett Construction Inc. | Construction | $719,113 | $721,950 | 49 | $14.9M | Research |
| Kronick Kalada Berdy & Company, P.c. | Professional, Scientific, and Technical Services | $661,762 | $667,110 | 43 | $13.7M | Research |
| Professional Healthcare Association INC | Administrative and Support and Waste Management | $588,900 | $594,200 | 70 | $11.0M | Research |
| Medical Oncology Associates of Wyoming Valley PC | Health Care and Social Assistance | $526,200 | $531,001 | 40 | $7.9M | Research |
| Custom Staffing Solutions | Administrative and Support and Waste Management | $500,000 | $503,333 | 100 | $15.7M | Research |
| Bonner Chevrolet Co., Inc. | Retail Trade | $491,972 | $496,454 | 54 | $13.6M | Research |