| Watsontown Trucking Company | Transportation and Warehousing | $6,023,800 | $5,891,737 | 419 | $63.3M |  Research |
| Staiman Recycling Corporation | Administrative and Support and Waste Management | $1,579,957 | $1,586,623 | 135 | $25.5M | Research |
| T-Ross Brothers Construction, Inc. | Construction | $996,700 | $1,003,151 | 84 | $95.7M | Research |
| Diversified Treatment Alternative Centers LLC | Health Care and Social Assistance | $967,285 | $978,972 | 147 | $23.8M | Research |
| Milton Operating LLC | Health Care and Social Assistance | $882,370 | $893,718 | 124 | $21.1M | Research |
| Custom Container Solutions, LLC | Manufacturing | $731,393 | $738,106 | 82 | $20.0M | Research |
| Patton Warehousing, LLC | Administrative and Support and Waste Management | $379,600 | $384,609 | 44 | $8.3M | Research |
| Btr, Inc. | Transportation and Warehousing | $378,400 | $380,891 | 25 | $5.0M | Research |
| Christ Wesleyan Church | Other Services (except Public Administration) | $362,401 | $365,139 | 80 | N/A | Research |
| Keystone Sporting Arms, LLC | Manufacturing | $344,700 | $346,815 | 43 | $10.5M | Research |
| K.j.e., Llc. | Transportation and Warehousing | $318,799 | $205,064 | 16 | <$5M | Research |
| Milton Transportation, Inc. | Transportation and Warehousing | $302,700 | $304,693 | 29 | $5.8M | Research |
| Meadowbrook Christian School | Educational Services | $292,350 | $296,362 | 50 | N/A | Research |
| Golden Proportions Marketing, INC | Professional, Scientific, and Technical Services | $289,800 | $291,459 | 23 | <$5M | Research |
| Custom Care Pharmacy LLC | Retail Trade | $253,008 | $254,537 | 28 | <$5M | Research |
| Susquehanna Valley Mobility Services | Retail Trade | $213,600 | $215,166 | 15 | <$5M | Research |
| American Truck Plaza LLC | Retail Trade | $212,797 | $213,873 | 31 | $10.4M | Research |
| Rippon Enterprises LLC | Administrative and Support and Waste Management | $184,700 | $186,439 | 55 | $10.4M | Research |
| American Truck Plazas LLC | Other Services (except Public Administration) | $182,300 | $183,556 | 53 | $10.4M | Research |
| Susquehanna Valley Mobility Services | Other Services (except Public Administration) | $181,250 | $182,645 | 17 | <$5M | Research |
| Coup Agency | Finance and Insurance | $171,525 | $172,709 | 13 | $6.7M | Research |
| Susquehanna Valley Dental Health Associates | Health Care and Social Assistance | $164,640 | $165,706 | 15 | <$5M | Research |
| Susquehanna Valley Dental Health Associates | Health Care and Social Assistance | $164,600 | $165,573 | 17 | <$5M | Research |
| Crossroads Church of the Nazarene | Other Services (except Public Administration) | $162,000 | $163,052 | 43 | N/A | Research |
| Todd E. Sowers LLC | Accommodation and Food Services | $132,734 | $133,940 | 17 | <$5M | Research |