| Pan Pepin INC | Manufacturing | $3,893,000 | $3,945,447 | 460 | $162.4M |  Research |
| Jose Santiago Inc. | Wholesale Trade | $3,644,700 | $3,706,742 | 415 | $106.8M | Research |
| B. Fernandez & Hnos, Inc. | Wholesale Trade | $3,606,200 | $3,647,872 | 484 | $124.6M | Research |
| The Retail Group INC | Administrative and Support and Waste Management | $3,112,300 | $3,148,697 | 500 | $78.7M | Research |
| Puma Energy Caribe LLC | Wholesale Trade | $2,673,000 | $2,702,700 | 255 | $65.6M | Research |
| Plaza Health LLC | Retail Trade | $1,977,000 | $1,958,716 | 342 | $59.7M | Research |
| Universidad Central Del Caribe INC | Educational Services | $1,862,000 | $1,877,879 | 252 | N/A | Research |
| Caribbean University, INC | Educational Services | $1,555,000 | $1,574,524 | 430 | N/A | Research |
| Alvacom Employment Solutions, LLC | Administrative and Support and Waste Management | $1,486,100 | $1,500,424 | 381 | $60.0M | Research |
| Puerto Rico Wire Products, Inc. | Wholesale Trade | $1,174,110 | $1,184,644 | 175 | $53.6M | Research |
| Roger Electric Corp | Wholesale Trade | $1,096,000 | $1,104,859 | 185 | $56.7M | Research |
| Cadilac Uniform & Linen Supply LLC | Other Services (except Public Administration) | $1,082,600 | $1,088,494 | 159 | $30.4M | Research |
| Cadillac Uniform & Linen Supply, LLC | Other Services (except Public Administration) | $1,065,400 | $1,093,005 | 193 | $36.9M | Research |
| Universidad Central De Bayamon, INC | Educational Services | $1,031,400 | $1,042,115 | 221 | N/A | Research |
| Automeca Technical Collegeinc. | Educational Services | $1,025,900 | $1,032,226 | 195 | $41.0M | Research |
| Grupo Epem /toyota Bayamon | Retail Trade | $1,011,349 | $1,021,125 | 105 | $26.5M | Research |
| Automeca Technical College, INC | Educational Services | $999,700 | $1,008,642 | 203 | $42.6M | Research |
| Alproem Engineering Contractors, Corp. | Construction | $990,667 | $998,620 | 256 | $291.7M | Research |
| Alproem Engineering Contractors Corp. | Construction | $924,696 | $931,220 | 139 | $158.4M | Research |
| Luis Garraton LLC | Wholesale Trade | $883,915 | $891,183 | 117 | $30.1M | Research |
| Harris Paints, Corp | Manufacturing | $835,000 | $849,798 | 140 | $138.9M | Research |
| Tropigas De Puerto Rico, Inc. | Wholesale Trade | $827,900 | $832,617 | 143 | $36.8M | Research |
| Puma Energy Services (latam) S.a., Inc. | Professional, Scientific, and Technical Services | $821,000 | $822,685 | 31 | <$5M | Research |
| Sun Colors Digital Graphics, Inc. | Manufacturing | $815,492 | $823,511 | 118 | $117.0M | Research |
| American College of Puerto Rico INC | Educational Services | $809,500 | $813,907 | 187 | N/A | Research |