| Royale Blue Hospitality LLC | Accommodation and Food Services | $1,045,100 | $1,061,212 | 177 | $55.3M |  Research |
| Caribe Physician Plaza Corp | Health Care and Social Assistance | $1,028,900 | $1,038,732 | 200 | $46.3M | Research |
| P & C Auto Inc. | Retail Trade | $656,767 | $662,532 | 86 | $21.7M | Research |
| East Island Excursions Inc. | Administrative and Support and Waste Management | $324,400 | $326,653 | 52 | $16.4M | Research |
| East Island Excursions, Inc. | Transportation and Warehousing | $322,400 | $324,943 | 59 | $15.0M | Research |
| Laboratorio Clinico Y De Referencia De Fajardo INC | Unknown | $320,400 | $314,202 | 55 | N/A | Research |
| Fajardo Inn S.e. | Accommodation and Food Services | $296,884 | $299,243 | 40 | $12.5M | Research |
| Customed INC | Manufacturing | $260,000 | $0 | 46 | $12.8M | Research |
| Mar-Co Industries, Corp | Manufacturing | $225,400 | $227,785 | 41 | $40.7M | Research |
| Fajardo Inn S.e. | Accommodation and Food Services | $212,060 | $213,992 | 50 | $15.6M | Research |
| Servicios Medicos Integrados De Fajardo Psc | Health Care and Social Assistance | $176,400 | $178,581 | 50 | $15.7M | Research |
| Cueva Marina LLC | Accommodation and Food Services | $167,700 | $168,837 | 84 | $14.9M | Research |
| Fundacion Educativa Concepcion Martin INC | Unknown | $162,700 | $164,716 | 54 | N/A | Research |
| Cueva Marina LLC | Unknown | $161,300 | $163,110 | 109 | N/A | Research |
| Wally Castro Marine INC | Retail Trade | $143,400 | $144,448 | 23 | $6.0M | Research |
| Mpcpr Operating, LLC | Arts, Entertainment, and Recreation | $142,000 | $143,369 | 20 | <$5M | Research |
| Wally Castro Marine Inc. | Retail Trade | $134,700 | $135,811 | 21 | $5.5M | Research |
| Suarez Gas Inc. | Wholesale Trade | $134,300 | $135,423 | 28 | $7.2M | Research |
| Pasion Por El Fogon INC | Accommodation and Food Services | $134,000 | $134,878 | 32 | $5.7M | Research |
| Fundacion Educativa Concepcion Martin in | Educational Services | $131,500 | $132,841 | 36 | <$5M | Research |
| Grupo Coral INC | Accommodation and Food Services | $129,045 | $129,898 | 31 | $5.5M | Research |
| Gas Connection Corporation | Wholesale Trade | $124,300 | $125,339 | 28 | $7.2M | Research |
| Continuum Mentalcare Corporation | Unknown | $119,000 | $120,392 | 30 | N/A | Research |
| Kayaking Puerto Rico Adventures, Inc. | Professional, Scientific, and Technical Services | $100,100 | $101,360 | 23 | <$5M | Research |
| Innovare Solutions LLC | Unknown | $100,100 | $100,904 | 14 | N/A | Research |