| Borinquen Container Corp | Manufacturing | $1,325,600 | $1,334,069 | 187 | $185.5M | Research |
| Hatillo Cash & Carry INC | Retail Trade | $1,271,800 | $1,283,529 | 350 | $87.4M | Research |
| Corp De Servicios Medicos Primarios | Health Care and Social Assistance | $950,000 | $959,183 | 215 | N/A | Research |
| Corporacion De Servicios Medicos Primarios Y Prevencion De H | Health Care and Social Assistance | $675,500 | $681,185 | 242 | N/A | Research |
| Colegio Evangelico Capitan Correa INC | Educational Services | $363,400 | $366,630 | 78 | N/A | Research |
| Market Expert LLC | Retail Trade | $360,200 | $363,722 | 155 | $38.7M | Research |
| Colegio Evangelico Capitan Correa INC | Educational Services | $357,700 | $362,072 | 58 | N/A | Research |
| El Buen Cafe Inc. | Accommodation and Food Services | $268,500 | $270,163 | 74 | $13.1M | Research |
| Big & Little Construction Corp. | Construction | $263,200 | $265,269 | 67 | $20.8M | Research |
| Kobun Puerto Rico INC | Retail Trade | $259,200 | $260,921 | 39 | $9.8M | Research |
| Atlantic Auto Equipment Corp | Retail Trade | $227,900 | $229,419 | 38 | $9.6M | Research |
| Kobun Puerto Rico, Inc. | Retail Trade | $224,000 | $226,035 | 53 | $13.4M | Research |
| Manuel Rosa E Hijos INC | Retail Trade | $208,000 | $209,912 | 61 | $15.2M | Research |
| El Buen Cafe INC | Accommodation and Food Services | $200,200 | $202,691 | 124 | $22.0M | Research |
| Brothers Security Services INC | Administrative and Support and Waste Management | $195,100 | $196,878 | 81 | $11.9M | Research |
| Ferreteria Amador, Inc. | Retail Trade | $191,900 | $193,718 | 53 | $10.9M | Research |
| Damar of Pr Service INC | Retail Trade | $190,100 | $192,386 | 40 | $7.0M | Research |
| Sucn Espinosa Rivera INC | Agriculture, Forestry, Fishing and Hunting | $178,900 | $180,326 | 54 | $8.8M | Research |
| Comercial Hermanos Barreto | Retail Trade | $176,000 | $177,687 | 55 | $11.4M | Research |
| Development Management & Consulting Group INC | Professional, Scientific, and Technical Services | $150,600 | $151,658 | 15 | <$5M | Research |
| Learn & Grow Therapy Group | Health Care and Social Assistance | $149,700 | $150,794 | 38 | $10.3M | Research |
| Dawilmar Franco Ginorio | Health Care and Social Assistance | $138,000 | $139,303 | 8 | <$5M | Research |
| Hospital Veterinario San Francisco De Asis | Professional, Scientific, and Technical Services | $133,155 | $93,519 | 24 | <$5M | Research |
| Northshore Imaging Services | Health Care and Social Assistance | $118,200 | $118,745 | 11 | <$5M | Research |
| Empresa Curbelo Duran LLC | Retail Trade | $117,711 | $119,343 | 44 | $14.8M | Research |