| Centro De Salud De Lares, INC | Health Care and Social Assistance | $1,286,100 | $1,297,461 | 226 | N/A |  Research |
| Lares Medical Center INC | Health Care and Social Assistance | $223,800 | $226,455 | 61 | $10.9M | Research |
| Javier Velez | Agriculture, Forestry, Fishing and Hunting | $184,500 | $185,827 | 194 | $19.8M | Research |
| Nieves & Nieves Engineers and Contractors, Inc. | Construction | $184,300 | $186,353 | 50 | $57.0M | Research |
| Nieves & Nieves Engineers & Contractors Inc. | Construction | $184,300 | $186,061 | 35 | $39.9M | Research |
| Productores De Ctricos De La Montaa Inc. | Manufacturing | $165,200 | $167,233 | 133 | $46.9M | Research |
| Javier E Velez Ruiz | Agriculture, Forestry, Fishing and Hunting | $163,700 | $165,905 | 100 | $10.2M | Research |
| Productores De Citricos De La Montana Inc. | Wholesale Trade | $156,700 | $158,820 | 132 | $34.0M | Research |
| Emanuel Hospice Care INC | Health Care and Social Assistance | $139,800 | $141,431 | 31 | $5.3M | Research |
| Bim Contractors, LLC | Construction | $135,300 | $136,367 | 30 | $10.2M | Research |
| Emmanuel Hospice Care Incorporado | Health Care and Social Assistance | $130,300 | $131,230 | 27 | <$5M | Research |
| Cafe Oro De Puerto Rico, Inc. | Manufacturing | $106,100 | $107,409 | 25 | $8.8M | Research |
| Cafe Oro De Pr INC | Manufacturing | $103,300 | $103,592 | 25 | $8.8M | Research |
| Cafe Bistro Hacienda Lealtad Corp | Accommodation and Food Services | $80,500 | $70,014 | 5 | <$5M | Research |
| Hacienda Los Eucaliptos INC | Agriculture, Forestry, Fishing and Hunting | $76,000 | $76,904 | 37 | <$5M | Research |
| Hacienda Los Eucaliptos Inc. | Agriculture, Forestry, Fishing and Hunting | $74,700 | $75,115 | 45 | <$5M | Research |
| Edgardo Barreto Rodriguez | Wholesale Trade | $64,000 | $64,476 | 25 | $6.4M | Research |
| Finca Luciana Inc. | Agriculture, Forestry, Fishing and Hunting | $61,000 | $61,419 | 51 | $5.2M | Research |
| Cafe Bistro Hacienda Lealtad Corp | Accommodation and Food Services | $57,000 | $57,602 | 6 | <$5M | Research |
| Farmacia Cooperativa De Lares | Retail Trade | $51,600 | $52,298 | 13 | N/A | Research |
| Alma Pharmaceutical Enterprises INC | Retail Trade | $45,500 | $45,824 | 16 | <$5M | Research |
| Rr Laboratory Services, Inc. | Professional, Scientific, and Technical Services | $43,675 | $43,895 | 14 | <$5M | Research |
| Farmacia Lumen Mendez | Retail Trade | $42,800 | $43,068 | 9 | <$5M | Research |
| Morales Bakery Inc. | Manufacturing | $42,100 | $42,425 | 13 | <$5M | Research |
| Morales Bakery, Inc. | Manufacturing | $40,900 | $41,231 | 11 | <$5M | Research |