| Saint Luke's Memorial Hospital | Health Care and Social Assistance | $7,560,909 | $7,645,759 | 500 | N/A |  AI Deep Dive |
| Med Centro Inc. | Health Care and Social Assistance | $3,523,500 | $3,564,020 | 433 | N/A | AI Deep Dive |
| Individual Management and Consultant INC | Professional, Scientific, and Technical Services | $2,315,200 | $458,964 | 500 | $51.8M | AI Deep Dive |
| Serralles Hotel,inc | Accommodation and Food Services | $2,088,000 | $2,112,244 | 369 | $115.4M | AI Deep Dive |
| Prime Janitorial Service, Corp. | Administrative and Support and Waste Management | $1,803,900 | $1,821,137 | 500 | $108.3M | AI Deep Dive |
| Centros Sor Isolina Ferre, INC | Other Services (except Public Administration) | $1,457,000 | $1,440,396 | 319 | $60.9M | AI Deep Dive |
| Centros Sor Isolina Ferre Inc. | Health Care and Social Assistance | $1,143,500 | $1,157,476 | 275 | $44.5M | AI Deep Dive |
| Ponce Medical School Foundation Inc. | Other Services (except Public Administration) | $1,131,000 | $1,141,336 | 127 | N/A | AI Deep Dive |
| Centro Ararat INC | Unknown | $1,119,300 | $871,038 | 122 | N/A | AI Deep Dive |
| Construcciones Jose Carro, S.e. | Construction | $1,035,000 | $1,045,034 | 54 | $16.7M | AI Deep Dive |
| One to Seven INC | Retail Trade | $969,920 | $982,313 | 450 | $105.9M | AI Deep Dive |
| Hotel Plaza Las Delicias Inc. | Accommodation and Food Services | $925,435 | $933,044 | 160 | $50.0M | AI Deep Dive |
| Prime Janitorial Metro and Health INC | Administrative and Support and Waste Management | $858,500 | $868,420 | 435 | $94.2M | AI Deep Dive |
| Ponce De Leon Hospitality Corp. | Accommodation and Food Services | $816,700 | $823,846 | 70 | $21.9M | AI Deep Dive |
| Caribbean Imaging and Radiation Treatment Center INC | Health Care and Social Assistance | $697,400 | $703,483 | 76 | $23.9M | AI Deep Dive |
| Caribbean Imaging and Radiation Treatmen | Health Care and Social Assistance | $697,100 | $702,444 | 77 | $15.3M | AI Deep Dive |
| Hotel Plaza Las Delicias, INC | Accommodation and Food Services | $648,000 | $654,300 | 160 | $50.0M | AI Deep Dive |
| Southern Pathology Services INC | Health Care and Social Assistance | $614,100 | $618,962 | 110 | $25.5M | AI Deep Dive |
| Comercio Cash & Carry, Inc. | Retail Trade | $594,800 | $602,846 | 246 | $61.4M | AI Deep Dive |
| Ponce De Leon Hospitality, Corp. | Accommodation and Food Services | $583,400 | $590,174 | 148 | $46.3M | AI Deep Dive |
| Ciracet Corp | Professional, Scientific, and Technical Services | $481,100 | $485,016 | 70 | $8.6M | AI Deep Dive |
| Caribe General Constructors INC | Construction | $480,000 | $483,973 | 69 | $78.6M | AI Deep Dive |
| Venegas Construction Corp. | Construction | $470,000 | $476,489 | 70 | $79.8M | AI Deep Dive |
| Colomer & Suarez, Inc. | Wholesale Trade | $465,400 | $467,973 | 62 | $16.0M | AI Deep Dive |
| Ciracet, Corp. | Professional, Scientific, and Technical Services | $450,000 | $452,698 | 68 | $7.0M | AI Deep Dive |