| Martex Farms SE | Agriculture, Forestry, Fishing and Hunting | $1,422,700 | $1,431,592 | 325 | $33.2M |  Research |
| Campofresco, Corp. | Manufacturing | $884,282 | $892,363 | 159 | $56.1M | Research |
| Ms Mango Farm LLC | Agriculture, Forestry, Fishing and Hunting | $412,000 | $415,342 | 92 | $9.4M | Research |
| Centro De Hematologia Y Oncologia Del Sur, Csp | Health Care and Social Assistance | $410,400 | $81,133 | 14 | <$5M | Research |
| Ms Mango Farm LLC | Agriculture, Forestry, Fishing and Hunting | $381,100 | $385,557 | 111 | $11.3M | Research |
| Gan Eden Farm LLC | Agriculture, Forestry, Fishing and Hunting | $330,400 | $334,264 | 111 | $11.3M | Research |
| Constructora I Melendez LLC | Construction | $267,100 | $269,548 | 12 | <$5M | Research |
| Constructora I Melendez | Construction | $211,000 | $212,149 | 39 | $12.1M | Research |
| Southwest Construction Group LLC | Construction | $200,700 | $202,060 | 43 | $13.3M | Research |
| 3rd Millennium Genetics, LLC | Professional, Scientific, and Technical Services | $196,800 | $198,861 | 121 | $16.9M | Research |
| Southwest Construction Group LLC | Construction | $190,900 | $192,745 | 37 | $12.6M | Research |
| Bananera Costa Sur INC | Agriculture, Forestry, Fishing and Hunting | $181,800 | $184,062 | 130 | $13.3M | Research |
| Khatib Brothers Inc. | Retail Trade | $161,800 | $162,775 | 88 | $20.7M | Research |
| Rc Professionals & Construction Services, Corp. | Construction | $131,500 | $132,786 | 36 | $41.0M | Research |
| Andres Rodriguez | Agriculture, Forestry, Fishing and Hunting | $129,200 | $130,657 | 33 | <$5M | Research |
| Constructora L Barrios LLC | Construction | $121,400 | $122,523 | 41 | $46.7M | Research |
| Pedro Auto Sales INC | Retail Trade | $112,400 | $112,931 | 12 | <$5M | Research |
| Andres Rodriguez Morejon | Agriculture, Forestry, Fishing and Hunting | $108,400 | $109,635 | 50 | $5.1M | Research |
| Rc Professionals & Construction Services, Corp. | Construction | $100,200 | $101,135 | 25 | $28.5M | Research |
| Caribe Food and Spirits INC | Accommodation and Food Services | $99,498 | $100,938 | 30 | $5.3M | Research |
| Oscar Rodriguez | Agriculture, Forestry, Fishing and Hunting | $87,100 | $87,961 | 24 | <$5M | Research |
| Rico Tractor INC | Wholesale Trade | $80,900 | $81,531 | 8 | <$5M | Research |
| Orlando Escalera Alamo | Agriculture, Forestry, Fishing and Hunting | $75,000 | $75,925 | 57 | $5.8M | Research |
| Caribe Food and Spirits INC | Accommodation and Food Services | $67,500 | $68,250 | 42 | $7.5M | Research |
| Oscar Rodriguez Morejon | Agriculture, Forestry, Fishing and Hunting | $66,300 | $67,022 | 34 | <$5M | Research |