| Centrocamiones INC | Retail Trade | $640,200 | $645,713 | 121 | $30.5M |  Research |
| Pan American Properties Corp | Manufacturing | $615,000 | $622,175 | 74 | $26.1M | Research |
| Centrocamiones Inc. | Retail Trade | $600,100 | $606,151 | 78 | $19.7M | Research |
| Engineered Parts and Services Inc. | Manufacturing | $498,700 | $502,773 | 58 | $15.2M | Research |
| Insular Trading Company INC | Wholesale Trade | $430,100 | $435,452 | 64 | $19.6M | Research |
| Productora De Agregados Inc. | Manufacturing | $350,200 | $351,737 | 55 | $54.6M | Research |
| Jjc Industrial Services Inc. | Other Services (except Public Administration) | $312,100 | $314,666 | 46 | $9.9M | Research |
| Toledo & Co LLC | Administrative and Support and Waste Management | $308,900 | $310,976 | 32 | <$5M | Research |
| Toledo & Co LLC | Administrative and Support and Waste Management | $294,500 | $297,020 | 31 | <$5M | Research |
| Correa Tire Distributors,inc | Wholesale Trade | $248,215 | $250,311 | 57 | $17.5M | Research |
| Puerto Rico Alarm Systems INC | Administrative and Support and Waste Management | $236,700 | $239,113 | 24 | <$5M | Research |
| Centro De Medicina Primaria De Vega Alta,corp. | Public Administration | $204,300 | $206,167 | 47 | N/A | Research |
| Academia Discipulos De Cristo | Educational Services | $161,600 | $136,028 | 53 | N/A | Research |
| Academia Discipulos De Cristo En Vega Al | Educational Services | $160,000 | $160,862 | 48 | N/A | Research |
| Vega Alta Hospice Care INC | Health Care and Social Assistance | $154,700 | $156,191 | 56 | $13.0M | Research |
| Hogar Ruth INC | Administrative and Support and Waste Management | $147,900 | $148,725 | 26 | <$5M | Research |
| J Torres Wooden Pallets Recycl | Manufacturing | $133,900 | $134,874 | 32 | $31.7M | Research |
| Farmacia Vega Alta INC | Retail Trade | $128,500 | $129,567 | 25 | <$5M | Research |
| Paitos Trucking INC | Transportation and Warehousing | $128,370 | $129,718 | 12 | <$5M | Research |
| Spider Telecom Construction, LLC | Construction | $125,000 | $126,281 | 30 | $34.2M | Research |
| Vega Alta Community Health INC | Health Care and Social Assistance | $123,400 | $124,442 | 45 | $10.4M | Research |
| Vega Alta Radiology, INC | Health Care and Social Assistance | $120,900 | $122,405 | 19 | <$5M | Research |
| Vega Alta Radiology | Health Care and Social Assistance | $120,900 | $121,847 | 20 | <$5M | Research |
| Medicos Selectos Del Norte Inc. | Public Administration | $118,700 | $119,838 | 19 | N/A | Research |
| Farmacia Vega Alta INC | Retail Trade | $114,500 | $115,839 | 25 | <$5M | Research |