| Calhoun Management Corporation | Accommodation and Food Services | $8,042,000 | $8,145,114 | 500 | $88.8M |  Research |
| Carc Inc. | Health Care and Social Assistance | $1,004,400 | $1,010,147 | 180 | $30.6M | Research |
| Excel Rehabilitation and Sports Enhancement, LLC | Health Care and Social Assistance | $609,370 | $615,227 | 41 | $11.1M | Research |
| Excel Rehabilitation and Sports Enhancement LLC | Health Care and Social Assistance | $566,305 | $572,173 | 155 | $41.9M | Research |
| Clemson University Continuing Education and Conference Compl | Accommodation and Food Services | $535,000 | $538,342 | 81 | N/A | Research |
| C J Priinting INC | Retail Trade | $406,000 | $410,260 | 121 | $36.6M | Research |
| C.j. Printing Inc. | Retail Trade | $403,000 | $407,637 | 52 | $15.7M | Research |
| Clemson University Continuing Education & Conference Center | Accommodation and Food Services | $384,500 | $387,460 | 85 | N/A | Research |
| Tiger Gourmet Foods Inc. | Accommodation and Food Services | $311,600 | $314,255 | 64 | $11.4M | Research |
| Crosspoint Church Clemson | Other Services (except Public Administration) | $269,052 | $270,726 | 30 | N/A | Research |
| Tiger Sports Shop, Inc. the | Retail Trade | $226,593 | $228,084 | 27 | $8.2M | Research |
| T&t Unlimited LLC | Accommodation and Food Services | $226,200 | $228,555 | 49 | $6.0M | Research |
| Tiger Gourmet Foods, INC | Accommodation and Food Services | $222,500 | $224,207 | 69 | $12.3M | Research |
| Backstreets of Clemson Inc. | Accommodation and Food Services | $219,396 | $221,236 | 60 | $10.7M | Research |
| Omnibond Systems LLC | Manufacturing | $217,300 | $219,135 | 22 | $5.8M | Research |
| Clemson United Methodist Church | Other Services (except Public Administration) | $214,808 | $216,335 | 40 | N/A | Research |
| Modjoul, Inc. | Information | $213,800 | $205,377 | 14 | <$5M | Research |
| Modjoul Inc. | Professional, Scientific, and Technical Services | $193,200 | $196,386 | 14 | <$5M | Research |
| The Tiger Sports Shop | Retail Trade | $193,141 | $193,930 | 23 | $7.0M | Research |
| Stancil Cooley Estep & Stamey LLP | Professional, Scientific, and Technical Services | $190,700 | $192,926 | 8 | <$5M | Research |
| C & M Enterprises, Inc. | Accommodation and Food Services | $188,268 | $192,096 | 40 | <$5M | Research |
| Abernathy of Clemson LLC the | Accommodation and Food Services | $180,453 | $181,826 | 14 | <$5M | Research |
| Geograph Technologies, LLC | Professional, Scientific, and Technical Services | $175,000 | $176,162 | 12 | <$5M | Research |
| Sparks & Associates Inc. | Professional, Scientific, and Technical Services | $167,100 | $168,647 | 30 | <$5M | Research |
| Sparks & Associates Inc. | Professional, Scientific, and Technical Services | $165,600 | $166,830 | 30 | <$5M | Research |