| Presbyterian College | Educational Services | $4,530,705 | $4,582,467 | 347 | N/A |  Research |
| Thornwell Home for Children | Health Care and Social Assistance | $1,303,162 | $1,309,967 | 147 | N/A | Research |
| Thornwell | Health Care and Social Assistance | $1,181,350 | $1,189,324 | 128 | N/A | Research |
| Palmetto Bone and Joint PA | Health Care and Social Assistance | $704,100 | $708,325 | 53 | $16.6M | Research |
| Carolina Concrete Co., Inc. | Manufacturing | $515,185 | $518,162 | 49 | $48.6M | Research |
| Southern Aluminum Foundry & Machine INC | Manufacturing | $398,095 | $402,905 | 38 | $9.9M | Research |
| Lanford Welding & Mechanical, Inc. | Other Services (except Public Administration) | $382,620 | $388,157 | 27 | $5.8M | Research |
| Lanford Welding & Mechanical INC | Construction | $369,003 | $374,640 | 31 | $9.9M | Research |
| Lynn Cooper INC | Retail Trade | $340,704 | $343,997 | 28 | $7.1M | Research |
| New Age Ironworks LLC | Manufacturing | $211,803 | $213,385 | 23 | $5.6M | Research |
| Alternator Exchange Inc. | Other Services (except Public Administration) | $208,955 | $211,549 | 25 | <$5M | Research |
| Dempsey's Pizza LLC | Accommodation and Food Services | $204,546 | $206,801 | 76 | $13.5M | Research |
| Resource Electric LLC | Construction | $196,245 | $197,766 | 13 | <$5M | Research |
| Alternator Exchange, Inc. | Manufacturing | $191,900 | $193,619 | 25 | $6.5M | Research |
| Resource Electric LLC | Construction | $184,883 | $187,055 | 13 | <$5M | Research |
| DC Capital LLC | Real Estate and Rental and Leasing | $160,970 | $164,092 | 11 | <$5M | Research |
| Thornwell Charter School | Educational Services | $158,401 | $159,497 | 20 | N/A | Research |
| Blue Ocean Seafood Restaurant INC | Accommodation and Food Services | $155,699 | $156,616 | 135 | $24.0M | Research |
| Ml Woodbridge Clinton LLC | Accommodation and Food Services | $153,500 | $154,370 | 43 | $13.4M | Research |
| Peay & Associates, LLC | Professional, Scientific, and Technical Services | $141,545 | $142,949 | 9 | <$5M | Research |
| Clinton Veterinary Hospital | Professional, Scientific, and Technical Services | $134,662 | $135,747 | 25 | <$5M | Research |
| Sadler Apothecary, INC | Retail Trade | $132,242 | $132,973 | 13 | <$5M | Research |
| D & D Truck Services, LLC | Transportation and Warehousing | $123,022 | $123,767 | 16 | <$5M | Research |
| Piedmont Pediatrics | Health Care and Social Assistance | $121,075 | $121,791 | 13 | <$5M | Research |
| Matt Davis Insurance and Financial Services | Finance and Insurance | $120,404 | $121,290 | 13 | $6.7M | Research |