| S&s Darlington LLC | Accommodation and Food Services | $76,028 | $76,876 | 44 | $7.8M | Research |
| Mayflower Seafood Restaurant of Darlington, LLC | Accommodation and Food Services | $75,000 | $75,666 | 26 | <$5M | Research |
| Loving Arms Home Care LLC | Health Care and Social Assistance | $74,280 | $74,939 | 21 | <$5M | Research |
| Loving Arms Home Care LLC | Health Care and Social Assistance | $74,280 | $74,864 | 21 | <$5M | Research |
| Temple Free Will Baptist Temple Christian Academy | Educational Services | $70,040 | $70,289 | 22 | N/A | Research |
| Temple Free Will Baptist Temple Christian Academny | Other Services (except Public Administration) | $70,040 | $70,705 | 24 | N/A | Research |
| Darlington County Council On Aging | Health Care and Social Assistance | $68,900 | $65,265 | 18 | N/A | Research |
| Atlantic Land & Timber Co | Agriculture, Forestry, Fishing and Hunting | $66,975 | $67,351 | 8 | <$5M | Research |
| Atlantic Land and Timber Corporation | Agriculture, Forestry, Fishing and Hunting | $66,975 | $67,208 | 7 | <$5M | Research |
| Woodard Farms, Inc. | Agriculture, Forestry, Fishing and Hunting | $65,567 | $66,303 | 11 | <$5M | Research |
| Asset Technology Group Inc. | Professional, Scientific, and Technical Services | $65,300 | $65,803 | 8 | <$5M | Research |
| Tadlock's Painting Co. Inc. | Construction | $65,068 | $65,369 | 7 | <$5M | Research |
| Russco Networks LLC | Professional, Scientific, and Technical Services | $64,700 | $65,336 | 9 | <$5M | Research |
| T & B Inc. | Retail Trade | $64,100 | $64,516 | 8 | <$5M | Research |
| William J Tuck P.a. | Professional, Scientific, and Technical Services | $62,800 | $63,339 | 5 | <$5M | Research |
| Tadlock's Painting Compay, Inc. | Construction | $60,700 | $61,001 | 8 | <$5M | Research |
| Dargan, King & Knight, LLC | Agriculture, Forestry, Fishing and Hunting | $60,700 | $61,141 | 3 | <$5M | Research |
| Wilson's Auto Sales | Retail Trade | $59,284 | $59,736 | 3 | <$5M | Research |
| Evans Construction of the Carolinas, INC | Construction | $58,900 | $59,431 | 5 | <$5M | Research |
| Aesthetic Dentistry P.a. | Health Care and Social Assistance | $58,526 | $59,068 | 6 | <$5M | Research |
| Aesthetic Dentistry PA | Health Care and Social Assistance | $58,500 | $58,992 | 6 | <$5M | Research |
| Dean Lambert, Inc. | Transportation and Warehousing | $57,600 | $58,081 | 9 | <$5M | Research |
| Palmetto Pawn & Gun LLC | Retail Trade | $56,026 | $56,976 | 14 | <$5M | Research |
| Asset Technology Group Inc. | Wholesale Trade | $54,200 | $54,580 | 6 | <$5M | Research |
| Free Medical Clinic of Darlington County | Health Care and Social Assistance | $53,817 | $46,473 | 5 | N/A | Research |