| Pegasus Steel LLC | Manufacturing | $1,947,225 | $1,966,210 | 111 | $27.1M |  Research |
| O.l. Thompson Construction Co. Inc. | Construction | $1,796,522 | $1,809,647 | 209 | $64.8M | Research |
| O. L. Thompson Construction Co., Inc. | Construction | $1,712,358 | $1,732,858 | 145 | $165.2M | Research |
| Pegasus Steel LLC | Manufacturing | $1,702,500 | $1,719,714 | 114 | $27.9M | Research |
| C R Hipp Construction INC | Construction | $1,079,323 | $1,091,329 | 80 | $25.3M | Research |
| C2g, Ltd Co. | Professional, Scientific, and Technical Services | $898,618 | $908,552 | 95 | $13.3M | Research |
| Quality Electric of the Coastal Carolinas INC | Construction | $823,900 | $828,369 | 75 | $22.8M | Research |
| Quality Electric of the Coastal Carolinas INC | Construction | $813,255 | $820,541 | 75 | $22.8M | Research |
| Allstate Crane Rental, Inc. | Real Estate and Rental and Leasing | $503,055 | $509,340 | 21 | $9.5M | Research |
| Big Red INC | Wholesale Trade | $502,032 | $508,307 | 34 | $10.4M | Research |
| Big Red, INC | Wholesale Trade | $439,900 | $444,922 | 33 | $10.1M | Research |
| Phillips Industrial Services Corporation | Construction | $377,598 | $379,398 | 33 | $8.3M | Research |
| Phillips Industrial Services Corporation | Construction | $377,598 | $380,360 | 29 | $7.3M | Research |
| Goose Creek Family Dentistry | Health Care and Social Assistance | $334,835 | $339,792 | 34 | $7.9M | Research |
| Greider LLC | Construction | $309,372 | $312,079 | 19 | $6.0M | Research |
| Trash Gurl LLC | Administrative and Support and Waste Management | $299,600 | $301,755 | 40 | $7.6M | Research |
| Goose Creek Family Dentistry | Health Care and Social Assistance | $297,933 | $302,187 | 34 | $7.9M | Research |
| Thompson Trucking Co. Inc. | Transportation and Warehousing | $296,347 | $298,232 | 27 | $7.2M | Research |
| Goose Creek Heating & Air | Construction | $288,427 | $292,136 | 25 | $7.9M | Research |
| Thompson Trucking Co., Inc. | Transportation and Warehousing | $274,352 | $276,295 | 24 | <$5M | Research |
| Linton's Mechanical, LLC | Manufacturing | $264,220 | $267,535 | 74 | $18.1M | Research |
| Trash Gurl LLC | Administrative and Support and Waste Management | $259,200 | $262,339 | 32 | $6.1M | Research |
| Pit Stop Service Center, INC | Other Services (except Public Administration) | $251,400 | $253,970 | 26 | $5.1M | Research |
| Glenda Stoll | Construction | $246,300 | $249,006 | 18 | $5.5M | Research |
| Tablecloth Shirt World LLC | Administrative and Support and Waste Management | $242,766 | $244,519 | 18 | <$5M | Research |