| The Index-Journal Company | Information | $453,100 | $457,845 | 45 | $7.6M |  Research |
| Bay Island Sportswear INC | Manufacturing | $422,059 | $424,451 | 42 | $14.8M | Research |
| Laminex Inc. | Manufacturing | $415,332 | $420,874 | 20 | $19.8M | Research |
| Greenwood Eye Clinic PA | Health Care and Social Assistance | $415,000 | $417,640 | 38 | $11.9M | Research |
| Greenwood Eye Clinic | Health Care and Social Assistance | $415,000 | $417,594 | 40 | $9.4M | Research |
| Central Packaging & Crating Inc. | Manufacturing | $408,700 | $410,268 | 50 | $49.6M | Research |
| Central Packaging & Crating, Inc. | Manufacturing | $408,700 | $410,771 | 58 | $57.5M | Research |
| Mathis Plumbing & Heating Company INC | Construction | $365,653 | $367,491 | 36 | $11.4M | Research |
| Mathis Plumbing & Heating Company, Inc. | Construction | $362,540 | $365,309 | 32 | $10.1M | Research |
| Manley Garvin, LLC | Professional, Scientific, and Technical Services | $355,700 | $358,061 | 23 | $7.3M | Research |
| Greenwood Obstetrics & Gynecology | Health Care and Social Assistance | $349,000 | $352,461 | 31 | $9.7M | Research |
| Wildcat Retro Brands LLC | Retail Trade | $342,946 | $345,270 | 41 | $12.4M | Research |
| Upper Savannah Council of Governments | Public Administration | $339,600 | $341,326 | 23 | N/A | Research |
| Laminex, Inc. | Manufacturing | $326,727 | $329,744 | 25 | $24.8M | Research |
| Keith Snead Builders Supply Company | Retail Trade | $313,562 | $317,499 | 27 | $5.6M | Research |
| Herbert Anderson, Jr. Construction, Inc. | Construction | $304,278 | $308,342 | 32 | $9.9M | Research |
| Mccravy, Newlon & Sturkie Law Firm | Professional, Scientific, and Technical Services | $300,900 | $302,630 | 41 | $10.0M | Research |
| Brick Oven of Greenwood LLC | Accommodation and Food Services | $298,337 | $300,086 | 50 | $8.9M | Research |
| Greenwood E.n.t. Association P.a. | Health Care and Social Assistance | $297,200 | $298,780 | 25 | $7.8M | Research |
| Cgc Recreation INC | Arts, Entertainment, and Recreation | $283,429 | $287,195 | 100 | $14.0M | Research |
| Town and Country Construction of South Carolina | Construction | $283,100 | $284,948 | 34 | $10.3M | Research |
| Greenwood Christian School | Other Services (except Public Administration) | $280,700 | $282,283 | 73 | N/A | Research |
| Gary Russ Chevrolet-Cadillac, INC | Retail Trade | $275,300 | $277,895 | 27 | $6.8M | Research |
| Greenwood Christian School | Educational Services | $272,095 | $273,584 | 64 | N/A | Research |
| Greenwood Ear, Nose and Throat Assoc PA | Health Care and Social Assistance | $271,700 | $273,489 | 22 | $6.9M | Research |