| Peters Murdaugh Parker Eltzroth & Detrick, PA | Professional, Scientific, and Technical Services | $896,260 | $1,016,376 | 68 | $16.5M |  Research |
| Brunson Construction, Inc. | Construction | $391,602 | $335,104 | 31 | $35.3M | Research |
| Brunson Construction, Inc. | Construction | $384,662 | $386,801 | 29 | $33.0M | Research |
| Coastal Air Technologies Inc. | Construction | $254,765 | $256,894 | 20 | $6.3M | Research |
| Coastal Air Technologies, INC | Construction | $209,775 | $236,594 | 34 | $10.8M | Research |
| Brunson Building Supply, Llc. | Construction | $130,892 | $149,015 | 25 | $28.5M | Research |
| Drs. Crews & Mills, Dental Associates, PA | Health Care and Social Assistance | $123,380 | $124,955 | 13 | <$5M | Research |
| New Life Center Commission On Alcohol & Other Drug Abuse | Health Care and Social Assistance | $78,805 | $115,214 | 12 | N/A | Research |
| Beaufort Pharmacy & Compounding LLC | Retail Trade | $78,100 | $78,624 | 9 | <$5M | Research |
| Peeples-Rhoden Funeral Home | Other Services (except Public Administration) | $69,671 | $70,273 | 12 | <$5M | Research |
| Hampton Foods LLC | Accommodation and Food Services | $63,300 | $63,937 | 22 | <$5M | Research |
| Sunco Exterior Solutions, LLC | Administrative and Support and Waste Management | $58,702 | $59,188 | 7 | <$5M | Research |
| Tuten's Fresh Market LLC | Retail Trade | $46,747 | $47,077 | 13 | <$5M | Research |
| Hampton County Insurance Agency, Inc. | Finance and Insurance | $46,660 | $46,948 | 3 | <$5M | Research |
| L&s Fabrication LLC | Professional, Scientific, and Technical Services | $46,562 | $46,918 | 6 | <$5M | Research |
| Glass Masters of Hampton LLC | Other Services (except Public Administration) | $44,129 | $44,446 | 3 | <$5M | Research |
| The Fairey Law Firm LLC | Professional, Scientific, and Technical Services | $41,501 | $41,872 | 6 | <$5M | Research |
| Horizon Landscaping & Irrigation LLC | Administrative and Support and Waste Management | $38,165 | $38,395 | 6 | <$5M | Research |
| The Fairey Law Firm, LLC | Professional, Scientific, and Technical Services | $37,915 | $38,161 | 5 | <$5M | Research |
| Gerald Brant | Administrative and Support and Waste Management | $36,209 | $36,491 | 2 | <$5M | Research |
| East Coast Electric LLC | Construction | $35,042 | $35,297 | 7 | <$5M | Research |
| Anderson & Brown, LLC | Professional, Scientific, and Technical Services | $34,637 | $39,896 | 4 | <$5M | Research |
| Alice B. Hazel CPA LLC | Professional, Scientific, and Technical Services | $34,627 | $38,422 | 4 | <$5M | Research |
| Robert M. Cook | Construction | $33,571 | $33,852 | 3 | <$5M | Research |
| Ellis Realty & Insurance Agency, INC | Real Estate and Rental and Leasing | $33,475 | $33,680 | 6 | <$5M | Research |