| Farmerstelephone Cooperative INC | Information | $6,621,332 | $6,696,071 | 281 | $47.2M |  Research |
| Santee Electric Cooperative, Inc. | Utilities | $2,887,500 | $2,919,618 | 123 | N/A | Research |
| Williamsburg Regional Hospital | Health Care and Social Assistance | $1,889,700 | $1,900,146 | 270 | N/A | Research |
| Palmetto Synthetics | Manufacturing | $1,860,700 | $1,806,376 | 198 | $196.4M | Research |
| Palmetto Synthetics LLC | Manufacturing | $1,795,700 | $1,805,687 | 197 | $195.4M | Research |
| Adams Life Link Ambulance, LLC | Health Care and Social Assistance | $670,372 | $674,525 | 86 | $19.9M | Research |
| Embroidery Solutions Manufacturing LLC | Manufacturing | $636,450 | $639,102 | 84 | $29.6M | Research |
| Embroidery Solutions Manufacturing, LLC | Manufacturing | $621,800 | $627,344 | 87 | $30.7M | Research |
| Andrews Fabricators of Kingstree, INC | Construction | $536,300 | $539,726 | 50 | $11.6M | Research |
| Andrews Fabricators of Kingstree Inc. | Construction | $530,678 | $533,774 | 69 | $16.0M | Research |
| Williamsburg County Disabilities and Special Needs Board | Public Administration | $525,625 | $0 | 115 | N/A | Research |
| Gary Mcclam Logging, Inc. | Agriculture, Forestry, Fishing and Hunting | $355,600 | $184,357 | 14 | <$5M | Research |
| Williamsburg Academy, Inc. | Educational Services | $273,200 | $275,097 | 45 | N/A | Research |
| Jimmie's Tree Service | Administrative and Support and Waste Management | $245,217 | $246,716 | 43 | $9.3M | Research |
| Boyd Electrical Services, INC | Construction | $243,200 | $245,098 | 16 | $5.3M | Research |
| Carlyle Senior Care of Kingstree LLC | Health Care and Social Assistance | $218,387 | $221,505 | 93 | $15.8M | Research |
| Watford Industry INC | Construction | $207,902 | $209,149 | 25 | $5.8M | Research |
| Jenkinson, Jarrett & Kellahan, PA | Professional, Scientific, and Technical Services | $193,900 | $195,699 | 17 | <$5M | Research |
| Mckenzie Farm Services, Inc. | Transportation and Warehousing | $185,400 | $186,775 | 15 | <$5M | Research |
| Williamsburg Packing Company, Inc. | Manufacturing | $178,100 | $179,599 | 32 | $11.3M | Research |
| Mckenzie Farm Services, Inc. | Transportation and Warehousing | $177,500 | $178,861 | 13 | <$5M | Research |
| Kellahan and Associates Engineers and Surveyors Inc. | Professional, Scientific, and Technical Services | $150,210 | $142,077 | 10 | <$5M | Research |
| Longstreet Sc LLC | Retail Trade | $149,500 | $151,106 | 31 | $7.8M | Research |
| Ash-Court Companion Care LLC | Health Care and Social Assistance | $145,029 | $146,076 | 53 | $9.1M | Research |
| Christopher Mckenzie | Transportation and Warehousing | $143,900 | $14,910 | 2 | <$5M | Research |