| Prc Laser Corporation | Manufacturing | $472,799 | $478,617 | 21 | $5.5M | Research |
| Trident Cardiology Associates, PA | Health Care and Social Assistance | $467,982 | $472,493 | 41 | $12.9M | Research |
| Lowcountry Case & Millwork | Manufacturing | $459,400 | $427,075 | 47 | $46.6M | Research |
| Center for Advanced Surgery, LLC | Health Care and Social Assistance | $386,633 | $391,519 | 39 | $12.2M | Research |
| Carolina Cataract & Laser Center, LLC | Health Care and Social Assistance | $282,350 | $286,664 | 26 | $8.2M | Research |
| Target Contractors LLC | Construction | $267,400 | $268,264 | 22 | $25.1M | Research |
| Brown Distribution Center, INC | Transportation and Warehousing | $259,369 | $261,678 | 35 | $5.3M | Research |
| Tri County Roofing INC | Construction | $253,532 | $256,849 | 21 | $6.9M | Research |
| Target Contractors LLC | Construction | $246,300 | $247,812 | 40 | $45.6M | Research |
| Bes Cleaning Inc. | Administrative and Support and Waste Management | $244,000 | $246,326 | 59 | $12.8M | Research |
| Jones Brothers Contracting | Construction | $229,200 | $230,894 | 29 | $7.3M | Research |
| King's Towing LLC | Transportation and Warehousing | $220,510 | $0 | 11 | <$5M | Research |
| Power Plus Systems, LLC | Construction | $219,045 | $222,406 | 17 | $5.6M | Research |
| North Charleston Hospitality Group LLC | Accommodation and Food Services | $196,114 | $198,360 | 26 | <$5M | Research |
| Southern Coast Specialists LLC | Health Care and Social Assistance | $183,200 | $185,554 | 13 | <$5M | Research |
| Design Build Construction, LLC | Construction | $179,600 | $181,117 | 17 | $19.4M | Research |
| Ristau Veterinary Care LLC | Professional, Scientific, and Technical Services | $178,955 | $180,769 | 15 | <$5M | Research |
| Keller Unlimited LLC | Accommodation and Food Services | $177,863 | $179,378 | 22 | <$5M | Research |
| 537 Doughnuts INC | Manufacturing | $173,300 | $175,057 | 35 | $12.4M | Research |
| Sullivan & Associates Inc. | Professional, Scientific, and Technical Services | $173,242 | $174,666 | 10 | <$5M | Research |
| Sullivan & Associates INC | Professional, Scientific, and Technical Services | $173,200 | $175,062 | 10 | <$5M | Research |
| Charleston Brace Company, LLC | Manufacturing | $168,478 | $170,083 | 12 | <$5M | Research |
| Eggs Over Nchas LLC | Accommodation and Food Services | $167,160 | $168,758 | 25 | <$5M | Research |
| Ladson Wood Recycling LLC | Agriculture, Forestry, Fishing and Hunting | $164,287 | $166,071 | 22 | <$5M | Research |
| Design Build Construction LLC | Construction | $154,442 | $156,441 | 11 | $12.5M | Research |